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DC Field | Value | Language |
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dc.contributor.author | Zwarte, Sonja M. C. de | - |
dc.contributor.author | Brouwer, Rachel M. | - |
dc.contributor.author | Agartz, Ingrid | - |
dc.contributor.author | Alda, Martin | - |
dc.contributor.author | Alonso Lana, Silvia | - |
dc.contributor.author | Bearden, Carrie E. | - |
dc.contributor.author | Bertolino, Alessandro | - |
dc.contributor.author | Bonvino, Aurora | - |
dc.contributor.author | Bramon, Elvira | - |
dc.contributor.author | Buimer, Elizabeth E.L. | - |
dc.contributor.author | Cahn, Wiepke | - |
dc.contributor.author | Canales Rodríguez, Erick Jorge | - |
dc.contributor.author | Cannon, Dara M. | - |
dc.contributor.author | Cannon, Tytone D. | - |
dc.contributor.author | Caseras, Xavier | - |
dc.contributor.author | Castro Fornieles, Josefina | - |
dc.contributor.author | Chen, Qiang | - |
dc.contributor.author | Chung, Yoonho | - |
dc.contributor.author | Serna Gómez, Elena de la | - |
dc.contributor.author | Bonnín, Caterina del Mar | - |
dc.contributor.author | Demro, Caroline | - |
dc.contributor.author | Di Giorgio, Annabella | - |
dc.contributor.author | Doucet, Gaelle E. | - |
dc.contributor.author | Eker, Mehmet Cagdas | - |
dc.contributor.author | Erk, Susanne | - |
dc.contributor.author | Fatjó-Vilas Mestre, Mar | - |
dc.contributor.author | Fears, SScott C. | - |
dc.contributor.author | Foley, Sonya F. | - |
dc.contributor.author | Frangou, Sophia | - |
dc.contributor.author | Fullerton, Janice M. | - |
dc.contributor.author | Glahn, David C. | - |
dc.contributor.author | Goghari, Vina M. | - |
dc.contributor.author | Goikolea, José Manuel | - |
dc.contributor.author | Goldman, Aaron L. | - |
dc.contributor.author | Gonul, Ali Saffet | - |
dc.contributor.author | Gruber, Oliver | - |
dc.contributor.author | Hajek, Tomas | - |
dc.contributor.author | Hawkins, Emma L. | - |
dc.contributor.author | Heinz, Andreas | - |
dc.contributor.author | Vieta i Pascual, Eduard, 1963- | - |
dc.date.accessioned | 2021-04-27T12:43:00Z | - |
dc.date.available | 2021-04-27T12:43:00Z | - |
dc.date.issued | 2020-10-07 | - |
dc.identifier.issn | 1065-9471 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176725 | - |
dc.description.abstract | First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10-5 ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/hbm.25206 | - |
dc.relation.ispartof | Human Brain Mapping, 2020 | - |
dc.relation.uri | https://doi.org/10.1002/hbm.25206 | - |
dc.rights | cc-by (c) Zwarte, Sonja M. C. de et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Esquizofrènia | - |
dc.subject.classification | Trastorn bipolar | - |
dc.subject.classification | Imatges per ressonància magnètica | - |
dc.subject.other | Schizophrenia | - |
dc.subject.other | Manic-depressive illness | - |
dc.subject.other | Magnetic resonance imaging | - |
dc.title | Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder Hum Brain Mapp | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 703711 | - |
dc.date.updated | 2021-04-27T12:43:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33027543 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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File | Description | Size | Format | |
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703711.pdf | 3.43 MB | Adobe PDF | View/Open |
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