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Title: Aortic remodelling induced by obstructive apneas is normalized with mesenchymal stem cells infusion
Author: Rubies, Cira
Dantas, Ana Paula
Batlle, Montserrat
Torres, Marta
Farré Ventura, Ramon
Sangüesa Puigventós, Gemma
Montserrat Canal, José Ma.
Mont Girbau, Lluís
Almendros López, Isaac
Guasch, Eduard
Keywords: Síndromes d'apnea del son
Cèl·lules mare
Sleep apnea syndromes
Stem cells
Issue Date: 7-Aug-2019
Publisher: Nature Publishing Group
Abstract: Obstructive sleep apnea syndrome (OSA) promotes aortic dilatation, increased stiffness and accelerated atherosclerosis, but the mechanisms of vascular remodelling are not known. We aimed to assess vascular remodelling, its mechanisms, and the effect of mesenchymal stem cells (MSC) infusions in a clinically relevant rat model of chronic OSA involving recurrent airway obstructions leading thoracic pressure swings and intermittent hypoxia/hypercapnia (OSA-rats). Another group of rats were placed in the same setup without air obstructions (Sham-rats) and were considered controls. Our study demonstrates that chronic, non-invasive repetitive airway obstructions mimicking OSA promote remarkable structural changes of the descending thoracic aorta such as eccentric aortic hypertrophy due to an increased wall thickness and lumen diameter, an increase in the number of elastin fibers which, in contrast, get ruptured, but no changes in tunica media fibrosis. As putative molecular mechanisms of the OSA-induced vascular changes we identified an increase in reactive oxygen species and renin-angiotensin system markers and an imbalance in oxide nitric synthesis. Our results also indicate that MSC infusion blunts the OSA-related vascular changes, most probably due to their anti-inflammatory properties.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2019, vol. 9, num. 1, p. 11443
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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