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Title: Renal size and cardiovascular risk in prepubertal children
Author: Lizarraga Mollinedo, Esther
Martínez Calcerrada, José María
Padrós Fornieles, Cristina
Mas Pares, Berta
Xargay i Torrent, Sílvia
Riera Pérez, Elena
Prats Puig, Anna
Carreras Badosa, Gemma
de Zegher, Francis
Ibáñez Toda, Lourdes
Bassols, Judit
López Bermejo, Abel
Keywords: Malalties del ronyó
Sistema cardiovascular
Kidney diseases
Cardiovascular system
Issue Date: 27-Mar-2019
Publisher: Nature Publishing Group
Abstract: Renal size is an important parameter for the evaluation and diagnosis of kidney disease and has been associated with several cardiovascular risk factors in patients with kidney failure. These results are however discordant and studies in healthy children are lacking. We aimed to study the association between renal size (length and volume) and cardiovascular risk parameters in healthy children. Clinical, analytical and ultrasound parameters [renal length, renal volume, perirenal fat and carotid intima-media thickness (cIMT)] were determined in 515 healthy prepubertal children (176 lean, 208 overweight and 131 obese). Renal length and volume associated significantly and positively with several anthropometric and cardiovascular risk parameters including cIMT and systolic blood pressure (SBP) (all p < 0.001). Renal length and volume associated with cIMT and SBP in all study subgroups, but these associations were predominant in obese children, in whom these associations were independent after adjusting for age, gender and BSA (all p < 0.05). In multivariate analyses in the study subjects as a whole, renal length was an independent predictor of cIMT (β = 0.310, p < 0.0001) and SBP (β = 0.116, p = 0.03). Renal size associates with cIMT and SBP, independent of other well-established cardiovascular risk factors, and may represent helpful parameters for the early assessment of cardiovascular risk in children.
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It is part of: Scientific Reports, 2019, vol. 9, num. 1, p. 5265
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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