Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/176797
Title: Insulin signalling regulates fatty acid catabolisme at the level of CoA activation
Author: Xu, Xiaojun
Gopalacharyullu, Peddinti
Seppanen-Laakso, Tuulikki
Ruskeepaa, Anna-Liisa
Aye, Cho-Cho
Carson, Brian P.
Mora Fayos, Sílvia
Oresic, Matej
Teleman, Aurelio A.
Keywords: Insulina
Teixit adipós
Insulin
Adipose tissues
Issue Date: 19-Jan-2012
Publisher: Public Library of Science (PLoS)
Abstract: The insulin/IGF signaling pathway is a highly conserved regulator of metabolism in flies and mammals, regulating multiple physiological functions including lipid metabolism. Although insulin signaling is known to regulate the activity of a number of enzymes in metabolic pathways, a comprehensive understanding of how the insulin signaling pathway regulates metabolic pathways is still lacking. Accepted knowledge suggests the key regulated step in triglyceride (TAG) catabolism is the release of fatty acids from TAG via the action of lipases. We show here that an additional, important regulated step is the activation of fatty acids for beta-oxidation via Acyl Co-A synthetases (ACS). We identify pudgy as an ACS that is transcriptionally regulated by direct FOXO action in Drosophila. Increasing or reducing pudgy expression in vivo causes a decrease or increase in organismal TAG levels respectively, indicating that pudgy expression levels are important for proper lipid homeostasis. We show that multiple ACSs are also transcriptionally regulated by insulin signaling in mammalian cells. In sum, we identify fatty acid activation onto CoA as an important, regulated step in triglyceride catabolism, and we identify a mechanistic link through which insulin regulates lipid homeostasis.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pgen.1002478
It is part of: PLoS Genetics, 2012, vol. 8, p. e1002478
URI: http://hdl.handle.net/2445/176797
Related resource: https://doi.org/10.1371/journal.pgen.1002478
ISSN: 1553-7390
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Files in This Item:
File Description SizeFormat 
711527.pdf1.04 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons