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http://hdl.handle.net/2445/176803
Title: | Renal size and cardiovascular risk in prepubertal children |
Author: | Lizarraga Mollinedo, Esther Martínez Calcerrada, José María Padrós Fornieles, Cristina Mas Pares, Berta Xargay i Torrent, Sílvia Riera Pérez, Elena Prats Puig, Anna Carreras Badosa, Gemma de Zegher, Francis Ibáñez Toda, Lourdes Bassols, Judit López Bermejo, Abel |
Keywords: | Malalties del ronyó Sistema cardiovascular Kidney diseases Cardiovascular system |
Issue Date: | 27-Mar-2019 |
Publisher: | Nature Publishing Group |
Abstract: | Renal size is an important parameter for the evaluation and diagnosis of kidney disease and has been associated with several cardiovascular risk factors in patients with kidney failure. These results are however discordant and studies in healthy children are lacking. We aimed to study the association between renal size (length and volume) and cardiovascular risk parameters in healthy children. Clinical, analytical and ultrasound parameters [renal length, renal volume, perirenal fat and carotid intima-media thickness (cIMT)] were determined in 515 healthy prepubertal children (176 lean, 208 overweight and 131 obese). Renal length and volume associated significantly and positively with several anthropometric and cardiovascular risk parameters including cIMT and systolic blood pressure (SBP) (all p < 0.001). Renal length and volume associated with cIMT and SBP in all study subgroups, but these associations were predominant in obese children, in whom these associations were independent after adjusting for age, gender and BSA (all p < 0.05). In multivariate analyses in the study subjects as a whole, renal length was an independent predictor of cIMT (β = 0.310, p < 0.0001) and SBP (β = 0.116, p = 0.03). Renal size associates with cIMT and SBP, independent of other well-established cardiovascular risk factors, and may represent helpful parameters for the early assessment of cardiovascular risk in children. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-41757-2 |
It is part of: | Scientific Reports, 2019, vol. 9, num. 1, p. 5265 |
URI: | http://hdl.handle.net/2445/176803 |
Related resource: | https://doi.org/10.1038/s41598-019-41757-2 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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