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DC Field | Value | Language |
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dc.contributor.author | Pellicé, Martina | - |
dc.contributor.author | Rodríguez Núñez, Olga | - |
dc.contributor.author | Rico, Verónica | - |
dc.contributor.author | Agüero, Daiana | - |
dc.contributor.author | Morata, Laura | - |
dc.contributor.author | Cardozo Espinola, Celia | - |
dc.contributor.author | Puerta Alcalde, Pedro | - |
dc.contributor.author | Garcia Vidal, Carolina | - |
dc.contributor.author | Rubio, Elisa | - |
dc.contributor.author | Fernández Pittol, Mariana José | - |
dc.contributor.author | Vergara Gómez, Andrea | - |
dc.contributor.author | Pitart, Cristina | - |
dc.contributor.author | Marco Reverté, Francesc | - |
dc.contributor.author | Santana, Gemina | - |
dc.contributor.author | Rodríguez Serna, Laura | - |
dc.contributor.author | Vilella i Morató, Anna | - |
dc.contributor.author | López, Ester | - |
dc.contributor.author | Soriano Viladomiu, Alex | - |
dc.contributor.author | Martínez, José Antonio (Martínez Martínez) | - |
dc.contributor.author | Del Rio, Ana | - |
dc.date.accessioned | 2021-04-28T10:15:12Z | - |
dc.date.available | 2021-04-28T10:15:12Z | - |
dc.date.issued | 2021-02-01 | - |
dc.identifier.issn | 1664-302X | - |
dc.identifier.uri | http://hdl.handle.net/2445/176835 | - |
dc.description.abstract | Background: KPC-producing Klebsiella pneumoniae (KPCKP) is a threat for patients admitted to healthcare institutions. Objectives: To assess the efficacy of several decolonization strategies for KPCKP rectal carriage. Methods: Observational study performed in a 750-bed university center from July to October 2018 on the efficacy of a 10-day non-absorbable oral antibiotic (NAA) regimen (colistin 10 mg/ml, amikacin 8 mg/ml, and nystatin 30 mg/ml, 10 ml/6 h) vs. the same regimen followed by a probiotic (Vivomixx®) for 20 days in adult patients with KPCKP rectal colonization acquired during an outbreak. Results: Seventy-three patients colonized by KPCKP were included, of which 21 (29%) did not receive any treatment and 52 (71.2%) received NAA either alone (n = 26, 35.6%) or followed by a probiotic (n = 26, 35.6%). Eradication was observed in 56 (76.7%) patients and the only variable significantly associated with it was not receiving systemic antibiotics after diagnosis of rectal carriage [22/24 (91.6%) vs. 34/49 (69.3%), p = 0.04]. Eradication in patients receiving NAA plus probiotic was numerically but not significantly higher than that of controls [23/26 (88.4%) vs. 15/21 (71.4%), p = 0.14] and of those receiving only NAA (OR = 3.4, 95% CI = 0.78-14.7, p = 0.09). Conclusion: In an outbreak setting, rectal carriage of KPCKP persisted after a mean of 36 days in about one quarter of patients. The only factor associated with eradication was not receiving systemic antibiotic after diagnosis. A 10-day course of NAA had no impact on eradication. Probiotics after NAA may increase the decolonization rate, hence deserving further study. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fmicb.2021.630826 | - |
dc.relation.ispartof | Frontiers in Microbiology, 2021, vol. 12, num. 630826 | - |
dc.relation.uri | https://doi.org/10.3389/fmicb.2021.630826 | - |
dc.rights | cc-by (c) Pellicé, Martina et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Klebsiella pneumoniae | - |
dc.subject.classification | Farmacologia | - |
dc.subject.other | Klebsiella pneumoniae | - |
dc.subject.other | Pharmacology | - |
dc.title | Factors Associated With Short-Term Eradication of Rectal Colonization by KPC-2 Producing Klebsiella pneumoniae in an Outbreak Setting | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 710599 | - |
dc.date.updated | 2021-04-28T10:15:12Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33597942 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
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710599.pdf | 784.68 kB | Adobe PDF | View/Open |
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