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Title: Neuregulin, an effector on mitochondria metabolism that preserves insulin sensitivity
Author: Gumà i Garcia, Anna Maria
Díaz Sáez, Francisco
Camps Camprubí, Marta
Zorzano Olarte, Antonio
Keywords: Mitocondris
Resistència a la insulina
Insulin resistance
Issue Date: 23-Jun-2020
Publisher: Frontiers Media
Abstract: Various external factors modulate the metabolic efficiency of mitochondria. This review focuses on the impact of the growth factor neuregulin and its ErbB receptors on mitochondria and their relationship with several physiopathological alterations. Neuregulin is involved in the differentiation of heart, skeletal muscle and the neuronal system, among others, and its deficiency is deleterious for the health. Information gathered over the last two decades suggests that neuregulin plays a key role regulating mitochondrial oxidative machinery, which sustain cell survival and insulin sensitivity.
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It is part of: Frontiers in Physiology, 2020, vol. 11, num. 696
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ISSN: 1664-042X
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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