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Title: 5-Hydroxytryptamine, Glutamate, and ATP: Much More Than Neurotransmitters
Author: Franco Fernández, Rafael
Rivas‐Santisteban, Rafael
Lillo, Jaume
Camps, Jordi
Navarro Brugal, Gemma
Reyes Resina, Irene
Keywords: Serotonina
Issue Date: 15-Apr-2021
Publisher: Frontiers Media
Abstract: 5-hydroxytryptamine (5-HT) is derived from the essential amino acid L-tryptophan. Although the compound has been studied extensively for its neuronal handling and synaptic actions, serotonin 5-HT receptors can be found extra-synaptically and not only in neurons but in many types of mammalian cells, inside and outside the central nervous system (CNS). In sharp contrast, glutamate (Glu) and ATP are better known as metabolism-related molecules, but they also are neurotransmitters, and their receptors are expressed on almost any type of cell inside and outside the nervous system. Whereas 5-hydroxytryptamine and Glu are key regulators of the immune system, ATP actions are more general. 5-hydroxytryptamine, ATP and Glu act through both G protein-coupled receptors (GPCRs), and ionotropic receptors, i.e., ligand gated ion channels. These are the three examples of neurotransmitters whose actions as holistic regulatory molecules are briefly put into perspective here.
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It is part of: Frontiers In Cell And Developmental Biology, 2021, vol. 9, num. 667815
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ISSN: 2296-634X
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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