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http://hdl.handle.net/2445/176918
Title: | Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections |
Author: | Lawal, Opeyemi U. Fraqueza, Maria J. Bouchami, Ons Worning, Peder Bartels, Mette D. Gonçalves, Maria L. Paixao, Paulo Gonçalves, Elsa Toscano, Cristina Empel, Joanna Urbás, Malgorzata Domínguez Luzón, Ma. Ángeles (María Ángeles) Westh, Henrik Lencastre, Hermínia de Miragaia, María |
Keywords: | Infeccions del tracte urinari Epidemiologia Estafilococs Urinary tract infections Epidemiology Staphylococcus |
Issue Date: | Mar-2021 |
Publisher: | Centers for Disease Control and Prevention |
Abstract: | Staphylococcus saprophyticus is a primary cause of community-acquired urinary tract infections (UTIs) in young women. S. saprophyticus colonizes humans and animals but basic features of its molecular epidemiology are undetermined. We conducted a phylogenomic analysis of 321 S. saprophyticus isolates collected from human UTIs worldwide during 1997-2017 and 232 isolates from human UTIs and the pig-processing chain in a confined region during 2016-2017. We found epidemiologic and genomic evidence that the meat-production chain is a major source of S. saprophyticus causing human UTIs; human microbiota is another possible origin. Pathogenic S. saprophyticus belonged to 2 lineages with distinctive generic features that are globally and locally disseminated. Pangenome-wide approaches identified a strong association between pathogenicity and antimicrobial resistance, phages, platelet binding proteins, and an increased recombination rate. Our study provides insight into the origin, transmission, and population structure of pathogenic S. saprophyticus and identifies putative new virulence factors. |
Note: | Reproducció del document publicat a: https://doi.org/10.3201/eid2703.200852 |
It is part of: | Emerging Infectious Diseases, 2021, vol. 27, num. 3, p. 880-893 |
URI: | http://hdl.handle.net/2445/176918 |
Related resource: | https://doi.org/10.3201/eid2703.200852 |
ISSN: | 1080-6040 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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711935.pdf | 4.85 MB | Adobe PDF | View/Open |
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