Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/176989
Title: | Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance |
Author: | Gudiol González, Carlota Albasanz Puig, Adaia Cuervo Requena, Guillermo Carratalà, Jordi |
Keywords: | Inflamació Immunosupressors Càncer Inflammation Immunosupressive agents Cancer |
Issue Date: | 31-Mar-2021 |
Publisher: | Frontiers Media S. A. |
Abstract: | Sepsis is a frequent complication in immunosuppressed cancer patients and hematopoietic stem cell transplant recipients that is associated with high morbidity and mortality rates. The worldwide emergence of antimicrobial resistance is of special concern in this population because any delay in starting adequate empirical antibiotic therapy can lead to poor outcomes. In this review, we aim to address: (1) the mechanisms involved in the development of sepsis and septic shock in these patients; (2) the risk factors associated with a worse prognosis; (3) the impact of adequate initial empirical antibiotic therapy given the current era of widespread antimicrobial resistance; and (4) the optimal management of sepsis, including adequate and early source control of infection, optimized antibiotic use based on the pharmacokinetic and pharmacodynamics changes in these patients, and the role of the new available antibiotics. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fmed.2021.636547 |
It is part of: | Frontiers in Medicine, 2021, vol. 8 |
URI: | http://hdl.handle.net/2445/176989 |
Related resource: | https://doi.org/10.3389/fmed.2021.636547 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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