Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/177006
Title: | Low birth weight as a potential risk factor for severe COVID-19 in adults |
Author: | Crispi Brillas, Fàtima Crovetto, Francesca Larroya, Marta Camacho Sáez, Alba Tortajada, Marta Sibila Vidal, Oriol Badia, Joan Ramon López, Marta Vellvé, Kilian García, Ferràn Trilla García, Antoni Faner, Rosa Blanco Vich, Isabel Borràs, Roger Agustí García-Navarro, Àlvar Gratacós Solsona, Eduard |
Keywords: | COVID-19 Pes corporal COVID-19 Body weight |
Issue Date: | 3-Feb-2021 |
Publisher: | Nature Publishing Group |
Abstract: | The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18-70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight ≤ 2.500 g. Age (adjusted OR (aOR) 1.04 [1-1.07], P = 0.012), male sex (aOR 3.39 [1.72-6.67], P < 0.001), hypertension (aOR 3.37 [1.69-6.72], P = 0.001), and LBW (aOR 3.61 [1.55-8.43], P = 0.003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0.79 [95% CI, 0.74-0.85], with positive and negative predictive values of 29.1% and 97.6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2.5%) needed ICU admission (AUC 0.74 [95% CI 0.68-0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-82389-9 |
It is part of: | Scientific Reports, 2021, vol. 11, num. 1, p. 2909 |
URI: | http://hdl.handle.net/2445/177006 |
Related resource: | https://doi.org/10.1038/s41598-021-82389-9 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
708697.pdf | 1.11 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License