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Title: Low birth weight as a potential risk factor for severe COVID-19 in adults
Author: Crispi Brillas, Fàtima
Crovetto, Francesca
Larroya, Marta
Camacho Sáez, Alba
Tortajada, Marta
Sibila Vidal, Oriol
Badia, Joan Ramon
López, Marta
Vellvé, Kilian
García, Ferràn
Trilla García, Antoni
Faner, Rosa
Blanco, Isabel
Borràs, Roger
Agustí García-Navarro, Àlvar
Gratacós Solsona, Eduard
Keywords: COVID-19
Pes corporal
Body weight
Issue Date: 3-Feb-2021
Publisher: Nature Publishing Group
Abstract: The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18-70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight ≤ 2.500 g. Age (adjusted OR (aOR) 1.04 [1-1.07], P = 0.012), male sex (aOR 3.39 [1.72-6.67], P < 0.001), hypertension (aOR 3.37 [1.69-6.72], P = 0.001), and LBW (aOR 3.61 [1.55-8.43], P = 0.003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0.79 [95% CI, 0.74-0.85], with positive and negative predictive values of 29.1% and 97.6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2.5%) needed ICU admission (AUC 0.74 [95% CI 0.68-0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2021, vol. 11, num. 1, p. 2909
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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