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Title: | IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status |
Author: | Ceausu, Andrea Rodríguez Gallego, Esther Perair, Joaquim López Dupla, Miguel Domingo, Pere (Domingo Pedrol) Viladés, Consuelo Vidal Gonzalez, Judit Peraire, María Perpiñán, Carles Pacheco, Yolanda María Veloso, Sergi Alba, Verónica Vargas, Montserrat Castellano, Alfonso J. Ruíz Mateos, Ezequiel Mallolas Masferrer, Josep Vidal, Francesc Rull, Anna |
Keywords: | Polimorfisme genètic Interleucines Genetic polymorphisms Interleukins |
Issue Date: | 31-Oct-2019 |
Publisher: | Nature Publishing Group |
Abstract: | A relationship between polymorphisms in genes encoding interleukin 7 (IL-7) and its cellular receptor (IL-7R) and antiretroviral therapy (ART)-associated immune recovery in HIV subjects has been previously reported. However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7/IL-7R levels is scarce. Here, we explored whether IL-7/IL-7R axis was associated with quantitative CD4+ T-cell recovery in HIV-infected subjects. IL-7/IL-7R polymorphisms were assessed by genotyping, and multiple inheritance models were used to estimate both, their association with low pre-ART CD4+ T-cell counts and incomplete immune recovery status after 48 weeks of suppressive ART. Integrated data from genetic variants association and soluble plasma IL-7/IL-7R quantification suggest that IL-7/IL-7R genotype expression could alter the homeostatic balance between soluble and membrane-bound receptors. The haplotype analyses indicates that allele combinations impacts pre-ART circulating CD4+ T-cell counts, immune recovery status and the absolute increment of CD4+ T-cell counts. The knowledge about how IL-7/IL-7R axis is related to quantitative CD4+ T-cell recovery and immune recovery status after initiating ART could be useful regarding T-cell reservoirs investigations in HIV subjects. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-52025-8 |
It is part of: | Scientific Reports, 2019, vol. 9, num. 1, p. 15722 |
URI: | http://hdl.handle.net/2445/177008 |
Related resource: | https://doi.org/10.1038/s41598-019-52025-8 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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