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DC Field | Value | Language |
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dc.contributor.author | Egli, Adrian | - |
dc.contributor.author | Mandal, Jyotshna | - |
dc.contributor.author | Schumann, Desiree M. | - |
dc.contributor.author | Roth, Michael | - |
dc.contributor.author | Thomas, Brad | - |
dc.contributor.author | Tyrrell, D. Lorne | - |
dc.contributor.author | Blasi, Francesco | - |
dc.contributor.author | Kostikas, Kostantinos | - |
dc.contributor.author | Boersma, Wim | - |
dc.contributor.author | Milenkovic, Branislava | - |
dc.contributor.author | Lacoma, Alicia | - |
dc.contributor.author | Rentsch, Katharina | - |
dc.contributor.author | Rohde, Gernot G. U. | - |
dc.contributor.author | Louis, Renaud | - |
dc.contributor.author | Aerts, Joachim G. | - |
dc.contributor.author | Welte, Tobias | - |
dc.contributor.author | Torres Martí, Antoni | - |
dc.contributor.author | Tamm, Michael | - |
dc.contributor.author | Stolz, Daiana | - |
dc.date.accessioned | 2021-05-05T15:39:42Z | - |
dc.date.available | 2021-05-05T15:39:42Z | - |
dc.date.issued | 2018-03-21 | - |
dc.identifier.issn | 1471-2466 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177028 | - |
dc.description.abstract | Background: Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations? Methods: Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PROMISE) study. The genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and circulating levels of IFNL3 in COPD patients were determined and associated with disease activity and outcome during a median follow-up of 24 months. Results: The GG genotype significantly influenced severe exacerbation rate (42 vs. 23%; p = 0.032) and time to severe exacerbation (HR = 2.260; p = 0.012). Compared to the TT or TG genotypes, the GG genotype was associated with severe dyspnoea (modified medical research council score ≥ median 3; 22 vs 42%, p = 0.030). The CC genotype of the rs12979860 SNP was associated with a poorer prognosis (body mass index, airflow obstruction, dyspnea and exercise capacity index ≥ median 4; 46 vs. 36% TC vs. 20.5% TT; p = 0.031). Patients with stable COPD and at exacerbation had significantly lower circulating IFNL3 compared to healthy controls (p < 0.001 and p < 0.001, respectively). Circulating IFNL3 correlated to post-bronchodilator FEV1%predicted and the tissue maturation biomarker Pro-collagen 3. Conclusion: IFNL3/4 polymorphisms and circulating IFNL3 may be associated with disease activity and outcomes in COPD. Trial registration: Clinical Trial registration http://www.isrctn.com/ identifier ISRCTN99586989 on 16 April 2008. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12890-018-0616-6 | - |
dc.relation.ispartof | BMC Pulmonary Medicine, 2018, vol. 18, num. 1, p. 51 | - |
dc.relation.uri | https://doi.org/10.1186/s12890-018-0616-6 | - |
dc.rights | cc-by (c) Egli, Adrian et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Mortalitat | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Polimorfisme genètic | - |
dc.subject.other | Mortality | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Genetic polymorphisms | - |
dc.title | IFN Lambda 3/4 locus polymorphisms and IFN Lambda 3 circulating levels are associated with COPD severity and outcomes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 697314 | - |
dc.date.updated | 2021-05-05T15:39:42Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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