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http://hdl.handle.net/2445/177068
Title: | Cytomegalovirus infection in HIV-infected patients in the era of combination antiretroviral therapy |
Author: | Perelló, R. Vergara, A. Jiménez, S. Montero, M. Saubi, N. Moreno, A. Eto, Y. Inciarte Portillo, Alexy Mallolas Masferrer, Josep Martínez, E. Marcos, Ma. Angeles |
Keywords: | Fòbies en els infants Suïcidi Phobias in children Suicide |
Issue Date: | 4-Dec-2019 |
Publisher: | BioMed Central |
Abstract: | Background: Cytomegalovirus infection dramatically decreased with the introduction of antiretroviral therapy. Whether incidence, clinical characteristics and prognosis of cytomegalovirus in HIV infected patients, has changed over time is. scarcely known. Methods: Retrospective single-center study. Patients included in this study were all HIV infected patients that went to our center for any disease, and were diagnosed with cytomegalovirus, during the period 2004-2015. epidemiological, clinical and laboratory patients variables were collected in a clinical database. Clinical characteristics, incidence of cytomegalovirus and predictors of mortality during the study were assessed. Results were considered statistically significant when p < 0.05. All statistical analyses were calculated by SPSS version 20.0 (Chicago, IL,USA). Results: Fifty-six cases of cytomegalovirus infection, in HIV infected patients were identified during the study period (incidence rate-1.7 cases per 1000 persons/year). The most frequent presentation was systemic illness in 43% of cases. Of note,no patients presented with ophthalmic manifestations. The 30-days mortality was 18%. Predictors of mortality were, in the univariate analysis, admission to the intensive care unit OR 32.4 (3.65-287.06) p = 0.0001, and mechanic ventilation 84 OR (8.27-853.12) p = 0.0001, and ART OR 4.1 (0.97-17.31) p = 0.044. These variables were assessed by multivariate analysis, and only mechanical ventilation was statistically significant (p < 0.05) CONCLUSION: Incidence of cytomegalovirus infection was higher than described in the antiretroviral therapy era. Clinical presentation has changed. Mechanic ventilation predicted mortality. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s12879-019-4643-6 |
It is part of: | BMC Infectious Diseases, 2019, vol. 19, num. 1, p. 1030 |
URI: | http://hdl.handle.net/2445/177068 |
Related resource: | https://doi.org/10.1186/s12879-019-4643-6 |
ISSN: | 1471-2334 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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