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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/177099
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dc.contributor.authorMartín-Gago, Pablo-
dc.contributor.authorGomez-Caminals, Marc-
dc.contributor.authorRamón, Rosario-
dc.contributor.authorVerdaguer i Espaulella, Xavier-
dc.contributor.authorMartin-Malpartida, Pau-
dc.contributor.authorAragón Altarriba, Eric-
dc.contributor.authorFernández-Carneado, Jimena-
dc.contributor.authorPonsati, Berta-
dc.contributor.authorLópez-Ruiz, Pilar-
dc.contributor.authorCortes, María Alicia-
dc.contributor.authorColás, Begoña-
dc.contributor.authorMacías Hernández, María J.-
dc.contributor.authorRiera i Escalé, Antoni-
dc.date.accessioned2021-05-07T10:41:07Z-
dc.date.available2021-05-07T10:41:07Z-
dc.date.issued2012-02-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/2445/177099-
dc.description.abstractGoing through the motions: Somatostatin analogues having greater conformational rigidity than somatostatin have been prepared by substituting Phe residues in the native sequence with mesityl alanine (Msa; see structure). The analogues show high affinity for SSTR receptors, thus showing that fine‐tuning of noncovalent interactions between amino acid side chains can modulate peptide affinity and selectivity.-
dc.format.extent6 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWiley-VCH-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/anie.201106406-
dc.relation.ispartofAngewandte Chemie-International Edition, 2012, vol. 51, num. 8, p. 1820-1825-
dc.relation.urihttps://doi.org/10.1002/anie.201106406-
dc.rights(c) Wiley-VCH, 2012-
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)-
dc.subject.classificationSomatostatina-
dc.subject.classificationPèptids-
dc.subject.otherSomatostatin-
dc.subject.otherPeptides-
dc.titleFine-tuning the [Pi]-[Pi]. Aromatic interactions in peptides: somatostatin analogues containing mesityl alanine-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec606258-
dc.date.updated2021-05-07T10:41:07Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
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