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http://hdl.handle.net/2445/177145
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DC Field | Value | Language |
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dc.contributor.author | Girona Alarcón, Mònica | - |
dc.contributor.author | Bobillo Pérez, Sara | - |
dc.contributor.author | Solé Ribalta, Anna | - |
dc.contributor.author | Hernández Platero, Lluisa | - |
dc.contributor.author | Guitart, Carmina | - |
dc.contributor.author | Suárez, Ricardo | - |
dc.contributor.author | Balaguer Gargallo, Mònica | - |
dc.contributor.author | Cambra Lasaosa, Francisco José | - |
dc.contributor.author | Jordán García, Iolanda | - |
dc.contributor.author | KIDS-Corona study group | - |
dc.contributor.author | Kids Corona Platform | - |
dc.date.accessioned | 2021-05-11T07:51:16Z | - |
dc.date.available | 2021-05-11T07:51:16Z | - |
dc.date.issued | 2020-01-20 | - |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177145 | - |
dc.description.abstract | Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has collapsed health systems worldwide. In adults, the virus causes severe acute respiratory distress syndrome (ARDS), while in children the disease seems to be milder, although a severe multisystem inflammatory syndrome (MIS-C) has been described. The aim was to describe and compare the characteristics of the severe COVID-19 disease in adults and children. Methods: This prospective observational cohort study included the young adults and children infected with SARS-CoV-2 between March-June 2020 and admitted to the paediatric intensive care unit. The two populations were analysed and compared focusing on their clinical and analytical characteristics and outcomes. Results: Twenty patients were included. There were 16 adults (80%) and 4 children (20%). No mortality was recorded. All the adults were admitted due to ARDS. The median age was 32 years (IQR 23.3-41.5) and the most relevant previous pathology was obesity (n = 7, 43.7%). Thirteen (81.3%) needed mechanical ventilation, with a median PEEP of 13 (IQR 10.5-14.5). Six (37.5%) needed inotropic support due to the sedation. Eight (50%) developed a healthcare-associated infection, the most frequent of which was central line-associated bloodstream infection (n = 7, 71.4%). One patient developed a partial pulmonary thromboembolism, despite him being treated with heparin. All the children were admitted due to MIS-C. Two (50%) required mechanical ventilation. All needed inotropic support, with a median vasoactive-inotropic score of 27.5 (IQR 17.5-30). The difference in the inotropic requirements between the two populations was statistically significant (37.5% vs. 100%, p < 0.001). The biomarker values were higher in children than in adults: mid-regional pro-adrenomedullin 1.72 vs. 0.78 nmol/L (p = 0.017), procalcitonin 5.7 vs. 0.19 ng/mL (p = 0.023), and C-reactive protein 328.2 vs. 146.9 mg/L (p = 0.005). N-terminal pro-B-type natriuretic peptide and troponins were higher in children than in adults (p = 0.034 and p = 0.039, respectively). Conclusions: Adults and children had different clinical manifestations. Adults developed severe ARDS requiring increased respiratory support, whereas children presented MIS-C with greater inotropic requirements. Biomarkers could be helpful in identifying susceptible patients, since they might change depending on the clinical features. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12879-021-05786-5 | - |
dc.relation.ispartof | BMC Infectious Diseases, 2020, vol. 21, num. 1, p. 87 | - |
dc.relation.uri | https://doi.org/10.1186/s12879-021-05786-5 | - |
dc.rights | cc-by (c) Girona Alarcón, Mónica et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Insuficiència respiratòria | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Respiratory insufficiency | - |
dc.title | The different manifestations of COVID-19 in adults and children: a cohort study in an intensive care unit | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 710003 | - |
dc.date.updated | 2021-05-11T07:51:16Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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