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http://hdl.handle.net/2445/177226
Title: | Overeating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study |
Author: | Lope, Virginia Martín, Miguel Castelló, Adela Ruiz, Amparo Casas, Ana Ma. Baena Cañada, José Manuel Antolín, Silvia Ramos-Vázquez, Manuel García-Sáenz, José Ángel Muñoz Mateu, Montserrat Lluch, Ana de Juan-Ferré, Ana Jara, Carlos Sánchez-Rovira, Pedro Antón, Antonio Chacón, José Ignacio Arcusa, Angels Jimeno, Mª Angeles Bezares Susana Vioque, Jesús Carrasco, Eva Pérez-Gómez, Beatriz Pollán, Marina |
Keywords: | Càncer de mama Calories dels aliments Condició física Breast cancer Food calories Physical fitness |
Issue Date: | 7-Mar-2019 |
Publisher: | Nature Publishing Group |
Abstract: | This study analyzes the association of excessive energy intake and caloric restriction with breast cancer (BC) risk taking into account the individual energy needs of Spanish women. We conducted a multicenter matched case-control study where 973 pairs completed lifestyle and food frequency questionnaires. Expected caloric intake was predicted from a linear regression model in controls, including calories consumed as dependent variable, basal metabolic rate as an ofset and physical activity as explanatory. Overeating and caloric restriction were defned taking into account the 99% confdence interval of the predicted value. The association with BC risk, overall and by pathologic subtype, was evaluated using conditional and multinomial logistic regression models. While premenopausal women that consumed few calories (>20% below predicted) had lower BC risk (OR=0.36; 95% CI=0.21-0.63), postmenopausal women with an excessive intake (≥40% above predicted) showed an increased risk (OR=2.81; 95% CI=1.65-4.79). For every 20% increase in relative (observed/predicted) caloric intake the risk of hormone receptor positive (p-trend<0.001) and HER2+ (p-trend=0.015) tumours increased 13%, being this fgure 7% for triple negative tumours. While high energy intake increases BC risk, caloric restriction could be protective. Moderate caloric restriction, in combination with regular physical activity, could be a good strategy for BC prevention. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-39346-4 |
It is part of: | Scientific Reports, 2019, vol. 9, p. 3904 |
URI: | http://hdl.handle.net/2445/177226 |
Related resource: | https://doi.org/10.1038/s41598-019-39346-4 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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