Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/177272
Title: | Development and Validation of an Early Mortality Risk Score for Older Patients Treated with Chemotherapy for Cancer |
Author: | Feliu, Jaime Pinto, Alvaro Basterretxea, Laura López San Vicente, Borja Paredero, Irene Llabrés, Elisenda Jiménez Munárriz, Beatriz Antonio, Maite Losada, Beatriz Espinosa, Enrique Gironés, Regina Custodio, Ana Belén Muñoz, Maria del Mar Díaz Almirón, Mariana Gómez Mediavilla, Jenifer Torregrosa, María Dolores Soler, Gema Cruz, Patricia Higuera, Oliver González Montalvo, Juan Ignacio Molina Garrido, María José |
Keywords: | Càncer Quimioteràpia Mortalitat Cancer Chemotherapy Mortality |
Issue Date: | 10-Apr-2021 |
Publisher: | MDPI |
Abstract: | Background: Estimation of life expectancy in older patients is relevant to select the best treatment strategy. We aimed to develop and validate a score to predict early mortality in older patients with cancer. Patients and Methods: A total of 749 patients over 70 years starting new chemotherapy regimens were prospectively included. A prechemotherapy assessment that included sociodemographic variables, tumor/treatment variables, and geriatric assessment variables was performed. Association between these factors and early death was examined using multivariable logistic regression. Score points were assigned to each risk factor. External validation was performed on an independent cohort. Results: In the training cohort, the independent predictors of 6-month mortality were metastatic stage (OR 4.8, 95% CI [2.4-9.6]), ECOG-PS 2 (OR 2.3, 95% CI [1.1-5.2]), ADL ≤ 5 (OR 1.7, 95% CI [1.1-3.5]), serum albumin levels ≤ 3.5 g/dL (OR 3.4, 95% CI [1.7-6.6]), BMI < 23 kg/m2 (OR 2.5, 95% CI [1.3-4.9]), and hemoglobin levels < 11 g/dL (OR 2.4, 95% CI (1.2-4.7)). With these results, we built a prognostic score. The area under the ROC curve was 0.78 (95% CI, 0.73 to 0.84), and in the validation set, it was 0.73 (95% CI: 0.67-0.79). Conclusions: This simple and highly accurate tool can help physicians making decisions in elderly patients with cancer who are planned to initiate chemotherapy treatment. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm10081615 |
It is part of: | Journal of Clinical Medicine, 2021, vol. 10, num. 8 |
URI: | http://hdl.handle.net/2445/177272 |
Related resource: | https://doi.org/10.3390/jcm10081615 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
jcm-10-01615-v2.pdf | 1.12 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License