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http://hdl.handle.net/2445/177301
Title: | Evaluation of renographic and metabolic parameters in human Kidney transplantation |
Author: | González Sistal, Ángel Vigués i Julià, Francesc Puchal Añé, Rafael Franco Miranda, Eladio Bartrons Bach, Ramon Ambrosio Viale, Santiago |
Keywords: | Trasplantament renal Diagnòstic per la imatge Metabolisme Kidney transplantation Diagnostic imaging Metabolism |
Issue Date: | 1-Mar-1997 |
Publisher: | The Society of Nuclear Medicine and Molecular Imaging |
Abstract: | Background: the aim of this work is to demonstrate that the value of the mean transit time (MTT) obtained from the 99mTc-MAG3 renogram deconvolution is related to the levels of adenine nucleotides determined in cortical biopsies from transplanted kidneys. Methods: the functional state was estimated by means of the MTT and the initial height (H0) of the renal retention function obtained from the 99mTc-MAG3 renogram deconvolution and by the measure of adenine nucleotides obtained from biopsies. We studied 30 kidney graft recipients, 25 normal functioning grafts (NFG) and 5 with acute tubular necrosis (ATN). Results: the MTT is significantly longer for ATN (p < 0.001). The initial uptake values (H0) are significantly lower for ATN (p < 0.001). The sum of adenine nucleotides (SAN) is significantly greater for NFG than for ATN (p < 0.001). The values of the MTT seem to reflect the energy state of the cells in transplanted kidney. Conclusion: the analysis of MTT may be indicative of the functional metabolic recovery and thus it may be predictive of the renal graft function at least in the same extent than the biochemical analysis of a cortical renal biopsy immediately after blood reperfusion of the tissue. |
Note: | Reproducció del document publicat a: |
It is part of: | Journal of Nuclear Medicine, 1997, vol. 41, num. 1, p. 42-45 |
URI: | http://hdl.handle.net/2445/177301 |
ISSN: | 0161-5505 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Ciències Fisiològiques) |
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