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|Release of hypoacetylated and trimethylated histone H4 is an epigenetic marker of early apoptosis
Fraga, Mario F.
Villar Garea, Ana
Casal, J. Ignacio
Cigudosa, Juan Cruz
Ballestar Tarín, Esteban
|American Society for Biochemistry and Molecular Biology
|Nuclear events such as chromatin condensation, DNA cleavage at internucleosomal sites, and histone release from chromatin are recognized as hallmarks of apoptosis. However, there is no complete understanding of the molecular events underlying these changes. It is likely that epigenetic changes such as DNA methylation and histone modifications that are involved in chromatin dynamics and structure are also involved in the nuclear events described. In this report we have shown that apoptosis is associated with global DNA hypomethylation and histone deacetylation events in leukemia cells. Most importantly, we have observed a particular epigenetic signature for early apoptosis defined by a release of hypoacetylated and trimethylated histone H4 and internucleosomal fragmented DNA that is hypermethylated and originates from perinuclear heterochromatin. These findings provide one of the first links between apoptotic nuclear events and epigenetic markers.
|Reproducció del document publicat a: https://doi.org/10.1074/jbc.M601136200
|It is part of:
|Journal of Biological Chemistry, 2006, vol. 281, num. 19, p. 13540-13547
|Appears in Collections:
|Articles publicats en revistes (Ciències Fisiològiques)
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