Please use this identifier to cite or link to this item:
Title: Release of hypoacetylated and trimethylated histone H4 is an epigenetic marker of early apoptosis
Author: Boix-Chornet, Manuel
Fraga, Mario F.
Villar Garea, Ana
Caballero, Rosalía
Espada, Jesús
Nuñez, Antonio
Casado, Juan
Largo, Cristina
Casal, J. Ignacio
Cigudosa, Juan Cruz
Franco, Luis
Esteller, Manel
Ballestar Tarín, Esteban
Keywords: Apoptosi
Issue Date: 12-May-2006
Publisher: American Society for Biochemistry and Molecular Biology
Abstract: Nuclear events such as chromatin condensation, DNA cleavage at internucleosomal sites, and histone release from chromatin are recognized as hallmarks of apoptosis. However, there is no complete understanding of the molecular events underlying these changes. It is likely that epigenetic changes such as DNA methylation and histone modifications that are involved in chromatin dynamics and structure are also involved in the nuclear events described. In this report we have shown that apoptosis is associated with global DNA hypomethylation and histone deacetylation events in leukemia cells. Most importantly, we have observed a particular epigenetic signature for early apoptosis defined by a release of hypoacetylated and trimethylated histone H4 and internucleosomal fragmented DNA that is hypermethylated and originates from perinuclear heterochromatin. These findings provide one of the first links between apoptotic nuclear events and epigenetic markers.
Note: Reproducció del document publicat a:
It is part of: Journal of Biological Chemistry, 2006, vol. 281, num. 19, p. 13540-13547
Related resource:
ISSN: 0021-9258
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

Files in This Item:
File Description SizeFormat 
700640.pdf504.93 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.