Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/177406
Title: | Innovative strategies to treat skin wounds with mangiferin: fabrication of transferosomes modified with glycols and mucin |
Author: | Allaw, Mohamad Pleguezuelos Villa, Maria Manca, Maria Letizia Caddeo, Carla Aroffu, Matteo Nacher, Amparo Díez Sales, Octavio Ruiz Sauri, Amparo Escribano Ferrer, Elvira Fadda, Anna Maria Manconi, Maria |
Keywords: | Malalties de la pell Glicols Skin diseases Glycols |
Issue Date: | 16-Apr-2020 |
Publisher: | Future Medicine |
Abstract: | im: The moisturizing properties of glycerol, the penetration enhancing capability of propylene glycol and the bioadhesive properties of mucin were combined to improve the carrier capabilities of transfersomes and the efficacy of mangiferin in the treatment of skin lesions. Materials & methods: Mangiferin was incorporated in transfersomes and glycoltransfersomes, which were also modified with mucin. The physico-chemical features were assessed, along with the efficacy against oxidative stress and skin wounds in vitro and in vivo. Results: Glycoltransfersomes promoted the deposition of mangiferin in epidermis and dermis, protected fibroblasts from oxidative stress and stimulated their proliferation. The wound healing and anti-inflammatory efficacy of glycoltransfersomes were confirmed in vivo. Conclusion: Results confirmed the potential of glycoltransfersomes in preventing/treating of skin lesions. |
Note: | Reproducció del document publicat a: https://doi.org/10.2217/nnm-2020-0116 |
It is part of: | Nanomedicine, 2020, vol. 15 , num. 17, p. 1671-1685 |
URI: | http://hdl.handle.net/2445/177406 |
Related resource: | https://doi.org/10.2217/nnm-2020-0116 |
ISSN: | 1743-5889 |
Appears in Collections: | Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB)) Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
707310.pdf | 31.27 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License