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Title: Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
Author: Gironés Petit, Robert
Cano Fernández, Amanda
Ortiz Rodrigo, Alba
Espina García, Marta
Prat Aixelà, Josefa
Muñoz Juncosa, Montserrat
Severino, Patrícia
Souto, Eliana B.
García López, María Luisa
Pujol Cubells, Montserrat
Sánchez-López, E. (Elena)
Keywords: Malalties de la pell
Skin diseases
Issue Date: 7-May-2021
Publisher: MDPI
Abstract: Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases. View Full-Text Keywords: skin inflammatory diseases; psoriasis; psoriasis versus atopic dermatitis; biodegradable nanoparticles; microneedles; clinical trials
Note: Reproducció del document publicat a:
It is part of: International Journal of Molecular Sciences, 2021, vol. 22, num. 9, p. 4983
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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