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Title: Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimer's disease
Author: Del Amo Albiol, Laura
Cano Fernández, Amanda
Ettcheto Arriola, Miren
Souto, Eliana B.
Espina García, Marta
Camins Espuny, Antoni
García, Maria Luisa
Sánchez-López, E. (Elena)
Keywords: Malaltia d'Alzheimer
Alzheimer's disease
Issue Date: 10-May-2021
Publisher: MDPI
Abstract: Alzheimer's disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Nanosized particles have been proposed as suitable drug delivery systems to overcome BBB with the purpose of increasing bioavailability of drugs in the brain. Biodegradable poly (lactic-co-glycolic acid) nanoparticles (PLGA-NPs) have been particularly regarded as promising drug delivery systems as they can be surface-tailored with functionalized molecules for site-specific targeting. In this review, a thorough discussion about the most recent functionalization strategies based on PLGA-NPs for AD and their mechanisms of action is provided, together with a description of AD pathogenesis and the role of the BBB in brain targeting. Keywords: functionalized PLGA nanoparticles; brain delivery; blood-brain barrier; Alzheimer's disease
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It is part of: Applied Sciences, 2021
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ISSN: 2076-3417
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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