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Title: RTP801 regulates motor cortex synaptic transmission and learning
Author: Pérez Sisqués, Leticia
Martín Flores, Núria
Masana Nadal, Mercè
Solana Balaguer, Júlia
Llobet, Arnau
Romaní Aumedes, Joan
Canal de la Iglesia, Mercè
Campoy Campos, Genís
García, Esther
Sánchez Fernández, Núria
Fernández García, Sara
Gilbert, James P.
Rodríguez Allué, Manuel José
Man, Heng-Ye
Feinstein, Elena
Williamson, David L.
Soto del Cerro, David
Gasull Casanova, Xavier
Alberch i Vié, Jordi
Malagelada Grau, Cristina
Keywords: Malaltia de Parkinson
Corea de Huntington
Models animals en la investigació
Parkinson's disease
Huntington's chorea
Animal models in research
Issue Date: 11-May-2021
Publisher: Elsevier
Abstract: Background: RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death in in vitro and in vivo models of Parkinson's and Huntington's diseases and is up regulated in compromised neurons in human postmortem brains of both neurodegenerative disorders. Indeed, in both Parkinson's and Huntington's disease mouse models, RTP801 knockdown alleviates motor-learning deficits. Results: We investigated the physiological role of RTP801 in neuronal plasticity and we found RTP801 in rat, mouse and human synapses. The absence of RTP801 enhanced excitatory synaptic transmission in both neuronal cultures and brain slices from RTP801 knock-out (KO) mice. Indeed, RTP801 KO mice showed improved motor learning, which correlated with lower spine density but increased basal filopodia and mushroom spines in the motor cortex layer V. This paralleled with higher levels of synaptosomal GluA1 and TrkB receptors in homogenates derived from KO mice motor cortex, proteins that are associated with synaptic strengthening.Conclusions: Altogether, these results indicate that RTP801 has an important role modulating neuronal plasticity and motor learning. They will help to understand its role in neurodegenerative disorders where RTP801 levels are detrimentally upregulated.
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It is part of: Experimental Neurology, 2021, vol. 342, p. 113755
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ISSN: 0014-4886
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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