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http://hdl.handle.net/2445/177533
Title: | Optical Control of GABAA Receptors with a Fulgimide-Based Potentiator |
Author: | Rustler, Karin Maleeva, Galyna Gomila Juaneda, Alexandre Gorostiza Langa, Pablo Ignacio Bregestovski, Piotr König, Burkhard |
Keywords: | Fototeràpia Neurotransmissió Phototherapy Neural transmission |
Issue Date: | 6-Oct-2020 |
Publisher: | Wiley-VCH GmbH |
Abstract: | Optogenetic and photopharmacological tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a pure potentiator of ionotropic γ-aminobutyric acid receptors (GABA A Rs) and displays full and reversible photoswitching in vitro and in vivo. The compound enables high-resolution studies of GABAergic neurotransmission, and phototherapies based on localized, acute, and reversible neuroinhibition. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/chem.202000710 |
It is part of: | Chemistry - A European Journal, 2020, vol. 26, num. 56, p. 12722-12727 |
URI: | http://hdl.handle.net/2445/177533 |
DOI: | https://doi.org/10.1002/chem.202000710 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Publicacions de projectes de recerca finançats per la UE |
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L01_2020_Chemistry - A European Journal_26_12722.pdf | 1.4 MB | Adobe PDF | View/Open |
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