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Title: Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study
Author: Mayén, Ana Lucia
Aglago, Elom K.
Knaze, Viktoria
Cordova, Reynalda
Schalkwijk, Casper G.
Wagner, Karl‐heinz
Aleksandrova, Krasimira
Fedirko, Veronika
Keski‐Rahkonen, Pekka
Leitzmann, Michael F.
Katzke, Verena
Srour, Bernard
Schulze, Matthias B.
Masala, Giovanna
Krogh, Vittorio
Panico, Salvatore
Tumino, Rosario
Bueno de Mesquita, H. Bas
Brustad, Magritt
Agudo, Antonio
Chirlaque, María Dolores
Amiano, Pilar
Ohlsson, Bodil
Ramne, Stina
Aune, Dagfinn
Weiderpass, Elisabete
Jenab, Mazda
Freisling, Heinz
Keywords: Carcinogènesi
Càncer de fetge
Liver cancer
Issue Date: 6-May-2021
Publisher: Wiley
Abstract: Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n = 450 111). Dietary intake of three AGEs, Nε -[carboxymethyl]lysine (CML), Nε -[1-carboxyethyl]lysine (CEL) and Nδ -[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with the risk of HCC (per 1 SD increment, HR-CML = 0.87, 95% CI: 0.76-0.99, HR-CEL = 0.84, 95% CI: 0.74-0.96 and HR-MH-G1 = 0.84, 95% CI: 0.74-0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-CML = 1.28, 95% CI: 1.05-1.56, HR-CEL = 1.17; 95% CI: 0.96-1.40, HR-MH-G1 = 1.27, 95% CI: 1.06-1.54). No associations were observed for cancers of the intra and extrahepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.
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It is part of: International Journal of Cancer, 2021
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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