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Title: Kainate receptor activation shapes short-term synaptic plasticity by controlling receptor lateral Mobility at glutamatergic synapses
Author: Polenghi, Alice
Nieus, Thierry
Guazzi, Stefania
Gorostiza Langa, Pablo Ignacio
Petrini, Enrica Maria
Barberis, Andrea
Keywords: Sinapsi
Receptors neurals
Neural receptor
Neural transmission
Issue Date: 16-Dec-2020
Abstract: Kainate receptors (KARs) mediate postsynaptic currents with a key impact on neuronal excitability. However, the molecular determinants controlling KAR postsynaptic localization and stabilization are poorly understood. Here, we exploit optogenetic and single-particle tracking approaches to study the role of KAR conformational states induced by glutamate binding on KAR lateral mobility at synapses. We report that following glutamate binding, KARs are readily and reversibly trapped at glutamatergic synapses through increased interaction with the β-catenin/N-cadherin complex. We demonstrate that such activation-dependent synaptic immobilization of KARs is crucial for the modulation of short-term plasticity of glutamatergic synapses. Thus, the present study unveils the crosstalk between conformational states and lateral mobility of KARs, a mechanism regulating glutamatergic signaling, particularly in conditions of sustained synaptic activity.
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It is part of: Cell Reports, 2020, vol. 31, num. 10, p. 107735
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Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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