Please use this identifier to cite or link to this item:
Title: Noninvasive imaging estimation of myocardial iron repletion following administration of intravenous iron: the myocardial-iron trial
Author: Nuñez, Julio
Miñana, Gema
Cardells, Ingrid
Palau, Patricia
Llàcer, Pau
Fácila, Lorenzo
Almenar, Luis
López-Lereu, Maria P.
Monmeneu, Jose V.
Amiguet, Martina
González, Jessika
Serrano, Alicia
Montagud, Vicente
López Vilella, Raquel
Valero, Ernesto
García-Blas, Sergio
Bodí, Vicent
Espriella-Juan, Rafael de la
Lupón, Josep
Navarro Pérez, Jorge
Górriz, José Luis
Sanchis Forés, Juan
Chorro, Francisco J.
Comín Colet, Josep
Bayés Genís, Antoni
Myocardial‐IRON Investigators
Keywords: Anèmia
Ressonància magnètica
Magnetic resonance
Issue Date: 13-Feb-2020
Publisher: American Heart Association
Abstract: Background: intravenous ferric carboxymaltose (FCM) improves symptoms, functional capacity, and quality of life in heart failure and iron deficiency. The mechanisms underlying these effects are not fully understood. The aim of this study was to examine changes in myocardial iron content after FCM administration in patients with heart failure and iron deficiency using cardiac magnetic resonance. Methods and Results: fifty‐three stable heart failure and iron deficiency patients were randomly assigned 1:1 to receive intravenous FCM or placebo in a multicenter, double‐blind study. T2* and T1 mapping cardiac magnetic resonance sequences, noninvasive surrogates of intramyocardial iron, were evaluated before and 7 and 30 days after randomization using linear mixed regression analysis. Results are presented as least‐square means with 95% CI. The primary end point was the change in T2* and T1 mapping at 7 and 30 days. Median age was 73 (65-78) years, with N‐terminal pro‐B‐type natriuretic peptide, ferritin, and transferrin saturation medians of 1690 pg/mL (1010-2828), 63 ng/mL (22-114), and 15.7% (11.0-19.2), respectively. Baseline T2* and T1 mapping values did not significantly differ across treatment arms. On day 7, both T2* and T1 mapping (ms) were significantly lower in the FCM arm (36.6 [34.6-38.7] versus 40 [38-42.1], P=0.025; 1061 [1051-1072] versus 1085 [1074-1095], P=0.001, respectively). A similar reduction was found at 30 days for T2* (36.3 [34.1-38.5] versus 41.1 [38.9-43.4], P=0.003), but not for T1 mapping (1075 [1065-1085] versus 1079 [1069-1089], P=0.577). Conclusions: in patients with heart failure and iron deficiency, FCM administration was associated with changes in the T2* and T1 mapping cardiac magnetic resonance sequences, indicative of myocardial iron repletion.
Note: Reproducció del document publicat a:
It is part of: Journal of the American Heart Association, 2020, vol. 9, num. 4, p. e014254
Related resource:
ISSN: 2047-9980
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

Files in This Item:
File Description SizeFormat 
702631.pdf1.21 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons