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http://hdl.handle.net/2445/177754
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DC Field | Value | Language |
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dc.contributor.author | Bello, Amaud del | - |
dc.contributor.author | Thaunat, Olivier | - |
dc.contributor.author | Quintrec, Moglie le | - |
dc.contributor.author | Bestard Matamoros, Oriol | - |
dc.contributor.author | Durrbach, Antoine | - |
dc.contributor.author | Perrin, Peggy | - |
dc.contributor.author | Gatault, Philippe | - |
dc.contributor.author | Jambon, Frederic | - |
dc.contributor.author | Pageaux, Georges-Philippe | - |
dc.contributor.author | Lladó Garriga, Laura | - |
dc.contributor.author | Besch, Camille | - |
dc.contributor.author | Barbier, Louise | - |
dc.contributor.author | Neau-Cransac, Martine | - |
dc.contributor.author | Dumortier, Jérôme | - |
dc.contributor.author | Kamar, Nassim | - |
dc.date.accessioned | 2021-05-27T17:38:37Z | - |
dc.date.available | 2021-05-27T17:38:37Z | - |
dc.date.issued | 2020-10-03 | - |
dc.identifier.issn | 2468-0249 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177754 | - |
dc.description.abstract | Introduction: the impact of preformed donor-specific anti-human leukocyte antigen (HLA) antibodies (pDSAs) after combined liver-kidney transplantation (CLKT) is still uncertain. Methods: we conducted a retrospective study in 8 European high-volume transplant centers and investigated the outcome of 166 consecutive CLKTs, including 46 patients with pDSAs. Results: patient survival was lower in those with pDSAs (5-year patient survival rate of 63% and 78% with or without pDSA, respectively; P = 0.04). The presence of pDSAs with a mean fluorescence intensity (MFI) ≥ 5000 (hazard ratio 4.96; 95% confidence interval: 2.3-10.9; P < 0.001) and the presence of 3 or more pDSAs (hazard ratio 6.5; 95% confidence interval: 2.5-18.8; P = 0.05) were independently associated with death. The death-censored liver graft survival was similar in patients with or without pDSAs. Kidney graft survival was comparable in both groups. (The 1- and 5-year death-censored graft survival rates were 91.6% and 79.5%, respectively, in patients with pDSAs and 93% and 88%, respectively, in the donor-specific antibody [DSA]-negative group, P = not significant). Despite a higher rate of kidney graft rejection in patients with pDSAs (5-year kidney graft survival rate without rejection of 87% and 97% with or without pDSAs, respectively; P = 0.04), kidney function did not statistically differ between both groups at 5 years post-transplantation (estimated glomerular filtration rate 45 ± 17 vs. 57 ± 29 ml/min per 1.73 m2, respectively, in patients with and without pDSAs). Five recipients with pDSAs (11.0%) experienced an antibody-mediated kidney rejection that led to graft loss in 1 patient. Conclusion: our results suggest that CLKT with pDSAs is associated with a lower patients' survival despite good recipients', liver and kidney grafts' outcome. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.ekir.2020.09.018 | - |
dc.relation.ispartof | Kidney International Reports, 2020, vol. 5, num. 12, p. 2202-2211 | - |
dc.relation.uri | https://doi.org/10.1016/j.ekir.2020.09.018 | - |
dc.rights | cc-by-nc-nd (c) International Society of Nephrology, 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Trasplantament d'òrgans | - |
dc.subject.classification | Fetge | - |
dc.subject.classification | Ronyó | - |
dc.subject.classification | Rebuig (Biologia) | - |
dc.subject.other | Transplantation of organs | - |
dc.subject.other | Liver | - |
dc.subject.other | Kidney | - |
dc.subject.other | Graft rejection | - |
dc.title | Combined Liver-Kidney Transplantation With Preformed Anti-human Leukocyte Antigen Donor-Specific Antibodies | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 706537 | - |
dc.date.updated | 2021-05-27T17:38:38Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33305113 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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