Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/177778
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hernández, Domingo | - |
dc.contributor.author | Alonso Titos, Juana | - |
dc.contributor.author | Vázquez, Teresa | - |
dc.contributor.author | León, Myriam | - |
dc.contributor.author | Caballero, Abelardo | - |
dc.contributor.author | Cobo, María Angeles | - |
dc.contributor.author | Sola, Eugenia | - |
dc.contributor.author | López, Verónica | - |
dc.contributor.author | Ruiz Esteban, Pedro | - |
dc.contributor.author | Cruzado, Josep Ma. | - |
dc.contributor.author | Sellarés, Joana | - |
dc.contributor.author | Moreso, Francesc | - |
dc.contributor.author | Manonelles, Anna | - |
dc.contributor.author | Torío, Alberto | - |
dc.contributor.author | Cabello, Mercedes | - |
dc.contributor.author | Delgado Burgos, Juan | - |
dc.contributor.author | Casas, Cristina | - |
dc.contributor.author | Gutiérrez, Elena | - |
dc.contributor.author | Jironda, Cristina | - |
dc.contributor.author | Kanter, Julia | - |
dc.contributor.author | Serón, Daniel | - |
dc.contributor.author | Torres, Armando | - |
dc.date.accessioned | 2021-05-28T09:29:37Z | - |
dc.date.available | 2021-05-28T09:29:37Z | - |
dc.date.issued | 2021-05-07 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177778 | - |
dc.description.abstract | The impact of corticosteroid withdrawal on medium-term graft histological changes in kidney transplant (KT) recipients under standard immunosuppression is uncertain. As part of an open-label, multicenter, prospective, phase IV, 24-month clinical trial (ClinicalTrials.gov, NCT02284464) in low-immunological-risk KT recipients, 105 patients were randomized, after a protocol-biopsy at 3 months, to corticosteroid continuation (CSC, n = 52) or corticosteroid withdrawal (CSW, n = 53). Both groups received tacrolimus and MMF and had another protocol-biopsy at 24 months. The acute rejection rate, including subclinical inflammation (SCI), was comparable between groups (21.2 vs. 24.5%). No patients developed dnDSA. Inflammatory and chronicity scores increased from 3 to 24 months in patients with, at baseline, no inflammation (NI) or SCI, regardless of treatment. CSW patients with SCI at 3 months had a significantly increased chronicity score at 24 months. HbA1c levels were lower in CSW patients (6.4 +/- 1.2 vs. 5.7 +/- 0.6%; p = 0.013) at 24 months, as was systolic blood pressure (134.2 +/- 14.9 vs. 125.7 +/- 15.3 mmHg; p = 0.016). Allograft function was comparable between groups and no patients died or lost their graft. An increase in chronicity scores at 2-years post-transplantation was observed in low-immunological-risk KT recipients with initial NI or SCI, but CSW may accelerate chronicity changes, especially in patients with early SCI. This strategy did, however, improve the cardiovascular profiles of patients. | - |
dc.format.extent | 18 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm10092005 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2021, vol. 10, num. 9 | - |
dc.relation.uri | https://doi.org/10.3390/jcm10092005 | - |
dc.rights | cc by (c) Hernández et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Trasplantament renal | - |
dc.subject.classification | Biòpsia | - |
dc.subject.classification | Corticosteroides | - |
dc.subject.other | Kidney transplantation | - |
dc.subject.other | Biopsy | - |
dc.subject.other | Adrenocortical hormones | - |
dc.title | Clinical Relevance of Corticosteroid Withdrawal on Graft Histological Lesions in Low-Immunological-Risk Kidney Transplant Patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-05-28T06:49:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34067039 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
jcm-10-02005.pdf | 1.04 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License