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https://hdl.handle.net/2445/177779
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DC Field | Value | Language |
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dc.contributor.author | Castro de Moura, Manuel | - |
dc.contributor.author | Davalos, Veronica | - |
dc.contributor.author | Planas Serra, Laura | - |
dc.contributor.author | Alvarez Errico, Damiana | - |
dc.contributor.author | Arribas, Carles | - |
dc.contributor.author | Ruiz, Montserrat | - |
dc.contributor.author | Aguilera Albesa, Sergio | - |
dc.contributor.author | Troya, Jesús | - |
dc.contributor.author | Valencia Ramos, Juan | - |
dc.contributor.author | Vélez Santamaria, Valentina | - |
dc.contributor.author | Rodríguez Palmero, Agustí | - |
dc.contributor.author | Villar García, Judit | - |
dc.contributor.author | Horcajada Gallego, Juan Pablo | - |
dc.contributor.author | Albu, Sergiu | - |
dc.contributor.author | Casasnovas Pons, Carlos | - |
dc.contributor.author | Rull, Anna | - |
dc.contributor.author | Reverte, Laia | - |
dc.contributor.author | Dietl, Beatriz | - |
dc.contributor.author | Dalmau, David | - |
dc.contributor.author | Arranz, Maria J. | - |
dc.contributor.author | Llucià-carol, Laia | - |
dc.contributor.author | Planas, Anna M. | - |
dc.contributor.author | Pérez Tur, Jordi | - |
dc.contributor.author | Fernández Cadenas, Israel | - |
dc.contributor.author | Villares, Paula | - |
dc.contributor.author | Tenorio, Jair | - |
dc.contributor.author | Colobran, Roger | - |
dc.contributor.author | Martin Nalda, Andrea | - |
dc.contributor.author | Soler Palacín, Pere | - |
dc.contributor.author | Vidal Marsal, Francisco | - |
dc.contributor.author | Pujol Onofre, Aurora | - |
dc.contributor.author | Esteller, Manel | - |
dc.date.accessioned | 2021-05-28T09:31:11Z | - |
dc.date.available | 2021-05-28T09:31:11Z | - |
dc.date.issued | 2021-04-01 | - |
dc.identifier.uri | https://hdl.handle.net/2445/177779 | - |
dc.description.abstract | Background: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation has been implicated in the regulation of viral infections and the immune system, we performed an epigenome-wide association study (EWAS) to identify candidate loci regulated by this epigenetic mark that could be involved in the onset of COVID-19 in patients without comorbidities. Methods: Peripheral blood samples were obtained from 407 confirmed COVID-19 patients ≤ 61 years of age and without comorbidities, 194 (47.7%) of whom had mild symptomatology that did not involve hospitalization and 213 (52.3%) had a severe clinical course that required respiratory support. The set of cases was divided into discovery (n = 207) and validation (n = 200) cohorts, balanced for age and sex of individuals. We analysed the DNA methylation status of 850,000 CpG sites in these patients. Findings: The DNA methylation status of 44 CpG sites was associated with the clinical severity of COVID-19. Of these loci, 23 (52.3%) were located in 20 annotated coding genes. These genes, such as the inflammasome component Absent in Melanoma 2 (AIM2) and the Major Histocompatibility Complex, class I C (HLA-C) candidates, were mainly involved in the response of interferon to viral infection. We used the EWAS-identified sites to establish a DNA methylation signature (EPICOVID) that is associated with the severity of the disease. Interpretation: We identified DNA methylation sites as epigenetic susceptibility loci for respiratory failure in COVID-19 patients. These candidate biomarkers, combined with other clinical, cellular and genetic factors, could be useful in the clinical stratification and management of patients infected with the SARS-CoV-2. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B. V. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.ebiom.2021.103339 | - |
dc.relation.ispartof | EBioMedicine, 2021, vol. 66 | - |
dc.relation.uri | https://doi.org/10.1016/j.ebiom.2021.103339 | - |
dc.rights | cc by-nc-nd (c) Castro de Moura et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | SARS-CoV-2 | - |
dc.subject.classification | Epigenètica | - |
dc.subject.classification | Insuficiència respiratòria | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | Epigenetics | - |
dc.subject.other | Respiratory insufficiency | - |
dc.title | Epigenome-wide association study of COVID-19 severity with respiratory failure | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-05-28T06:42:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32511103 | - |
dc.identifier.pmid | 33867313 | - |
dc.identifier.pmid | 716111 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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PIIS2352396421001328.pdf | 1.88 MB | Adobe PDF | View/Open |
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