Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/177779
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCastro de Moura, Manuel-
dc.contributor.authorDavalos, Veronica-
dc.contributor.authorPlanas Serra, Laura-
dc.contributor.authorAlvarez Errico, Damiana-
dc.contributor.authorArribas, Carles-
dc.contributor.authorRuiz, Montserrat-
dc.contributor.authorAguilera Albesa, Sergio-
dc.contributor.authorTroya, Jesús-
dc.contributor.authorValencia Ramos, Juan-
dc.contributor.authorVélez Santamaria, Valentina-
dc.contributor.authorRodríguez Palmero, Agustí-
dc.contributor.authorVillar García, Judit-
dc.contributor.authorHorcajada Gallego, Juan Pablo-
dc.contributor.authorAlbu, Sergiu-
dc.contributor.authorCasasnovas Pons, Carlos-
dc.contributor.authorRull, Anna-
dc.contributor.authorReverte, Laia-
dc.contributor.authorDietl, Beatriz-
dc.contributor.authorDalmau, David-
dc.contributor.authorArranz, Maria J.-
dc.contributor.authorLlucià-carol, Laia-
dc.contributor.authorPlanas, Anna M.-
dc.contributor.authorPérez Tur, Jordi-
dc.contributor.authorFernández Cadenas, Israel-
dc.contributor.authorVillares, Paula-
dc.contributor.authorTenorio, Jair-
dc.contributor.authorColobran, Roger-
dc.contributor.authorMartin Nalda, Andrea-
dc.contributor.authorSoler Palacín, Pere-
dc.contributor.authorVidal Marsal, Francisco-
dc.contributor.authorPujol Onofre, Aurora-
dc.contributor.authorEsteller, Manel-
dc.date.accessioned2021-05-28T09:31:11Z-
dc.date.available2021-05-28T09:31:11Z-
dc.date.issued2021-04-01-
dc.identifier.urihttps://hdl.handle.net/2445/177779-
dc.description.abstractBackground: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation has been implicated in the regulation of viral infections and the immune system, we performed an epigenome-wide association study (EWAS) to identify candidate loci regulated by this epigenetic mark that could be involved in the onset of COVID-19 in patients without comorbidities. Methods: Peripheral blood samples were obtained from 407 confirmed COVID-19 patients ≤ 61 years of age and without comorbidities, 194 (47.7%) of whom had mild symptomatology that did not involve hospitalization and 213 (52.3%) had a severe clinical course that required respiratory support. The set of cases was divided into discovery (n = 207) and validation (n = 200) cohorts, balanced for age and sex of individuals. We analysed the DNA methylation status of 850,000 CpG sites in these patients. Findings: The DNA methylation status of 44 CpG sites was associated with the clinical severity of COVID-19. Of these loci, 23 (52.3%) were located in 20 annotated coding genes. These genes, such as the inflammasome component Absent in Melanoma 2 (AIM2) and the Major Histocompatibility Complex, class I C (HLA-C) candidates, were mainly involved in the response of interferon to viral infection. We used the EWAS-identified sites to establish a DNA methylation signature (EPICOVID) that is associated with the severity of the disease. Interpretation: We identified DNA methylation sites as epigenetic susceptibility loci for respiratory failure in COVID-19 patients. These candidate biomarkers, combined with other clinical, cellular and genetic factors, could be useful in the clinical stratification and management of patients infected with the SARS-CoV-2.-
dc.format.extent10 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier B. V.-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.ebiom.2021.103339-
dc.relation.ispartofEBioMedicine, 2021, vol. 66-
dc.relation.urihttps://doi.org/10.1016/j.ebiom.2021.103339-
dc.rightscc by-nc-nd (c) Castro de Moura et al., 2021-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.sourceArticles publicats en revistes (Ciències Clíniques)-
dc.subject.classificationCOVID-19-
dc.subject.classificationSARS-CoV-2-
dc.subject.classificationEpigenètica-
dc.subject.classificationInsuficiència respiratòria-
dc.subject.otherCOVID-19-
dc.subject.otherSARS-CoV-2-
dc.subject.otherEpigenetics-
dc.subject.otherRespiratory insufficiency-
dc.titleEpigenome-wide association study of COVID-19 severity with respiratory failure-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.date.updated2021-05-28T06:42:05Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid32511103-
dc.identifier.pmid33867313-
dc.identifier.pmid716111-
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
PIIS2352396421001328.pdf1.88 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons