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Title: Locus coeruleus connectivity alterations in late-life major depressive disorder during a visual oddball task
Author: Cerro San Ildefonso, Inés del
Martínez Zalacaín, Ignacio
Guinea Izquierdo, Andrés
Gascón-Bayarri, Jordi
Viñas Díez, Vanesa
Urretavizcaya Sarachaga, Mikel
Naval Baudin, Pablo
Aguilera, Carles
Reñé Ramírez, Ramon
Ferrer, Isidro (Ferrer Abizanda)
Menchón Magriñá, José Manuel
Soria, Virginia
Soriano Mas, Carles
Keywords: Depressió psíquica
Ressonància magnètica
Mental depression
Magnetic resonance
Issue Date: 27-Oct-2020
Publisher: Elsevier
Abstract: The Locus Coeruleus (LC) is the major source of noradrenergic neurotransmission. Structural alterations in the LC have been observed in neurodegenerative disorders and at-risk individuals, although functional connectivity studies between the LC and other brain areas have not been yet performed in these populations. Patients with late-life major depressive disorder (MDD) are indeed at increased risk for neurodegenerative disorders, and here we investigated LC connectivity in late-life MDD in comparison to individuals with amnestic type mild cognitive impairment (aMCI) and healthy controls (HCs). We assessed 20 patients with late-life MDD, 16 patients with aMCI, and 26 HCs, who underwent a functional magnetic resonance scan while performing a visual oddball task. We assessed task-related modulations of LC connectivity (i.e., Psychophysiological Interactions, PPI) with other brain areas. A T1-weighted fast spin-echo sequence for LC localization was also obtained. Patients with late-life MDD showed lower global connectivity during target detection in a cluster encompassing the right caudal LC. Specifically, we observed lower LC connectivity with the left anterior cingulate cortex (ACC), the right fusiform gyrus, and different cerebellar clusters. Moreover, alterations in LC-ACC connectivity correlated negatively with depression severity (i.e., Geriatric Depression Scale and number of recurrences). Reduced connectivity of the LC during oddball performance seems to specifically characterize patients with late-life MDD, but not other populations of aged individuals with cognitive alterations. Such alteration is associated with different measures of disease severity, such as the current presence of symptoms and the burden of disease (number of recurrences).
Note: Reproducció del document publicat a:
It is part of: Neuroimage-Clinical, 2020, vol. 28, p. 102482
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ISSN: 2213-1582
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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