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http://hdl.handle.net/2445/177973
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DC Field | Value | Language |
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dc.contributor.author | Rubio-Rivas, Manuel | - |
dc.contributor.author | Corbella, Xavier | - |
dc.contributor.author | Formiga Pérez, Francesc | - |
dc.contributor.author | Menéndez Fernández, Estela | - |
dc.contributor.author | Martín Escalante, María Dolores | - |
dc.contributor.author | Baños Fernández, Isolina | - |
dc.contributor.author | Arnalich Fernández, Francisco | - |
dc.contributor.author | Corral-Beamonte, Esther del | - |
dc.contributor.author | Lalueza, Antonio | - |
dc.contributor.author | Parra Virto, Alejandro | - |
dc.contributor.author | Roy Vallejo, Emilia | - |
dc.contributor.author | Loureiro Amigo, José | - |
dc.contributor.author | Álvarez Suárez, Ana María | - |
dc.contributor.author | Abadía-Otero, Jesica | - |
dc.contributor.author | Navarro de la Chica, María | - |
dc.contributor.author | Estévez González, Raquel | - |
dc.contributor.author | Hernández Milián, Almudena | - |
dc.contributor.author | Areses Manrique, María | - |
dc.contributor.author | Blázquez Encinar, Julio César | - |
dc.contributor.author | González Noya, Amara | - |
dc.contributor.author | González Ferrer, Ruth | - |
dc.contributor.author | Pérez Aguilera, María | - |
dc.contributor.author | Gil Sánchez, Ricardo | - |
dc.contributor.author | Millán Núñez-Cortés, Jesús | - |
dc.contributor.author | Casas Rojo, José | - |
dc.contributor.author | SEMI-COVID-19 Network | - |
dc.date.accessioned | 2021-06-03T16:02:00Z | - |
dc.date.available | 2021-06-03T16:02:00Z | - |
dc.date.issued | 2021-05-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177973 | - |
dc.description.abstract | Background: the inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. Methods: retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. Results: a total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. Conclusion: the present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm10102214 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2021, vol. 10, num. 10, p. 2214 | - |
dc.relation.uri | https://doi.org/10.3390/jcm10102214 | - |
dc.rights | cc-by (c) Rubio-Rivas, Manuel et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Citoquines | - |
dc.subject.classification | Mortalitat | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Cytokines | - |
dc.subject.other | Mortality | - |
dc.title | Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 712249 | - |
dc.date.updated | 2021-06-03T16:02:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34065316 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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712249.pdf | 1.26 MB | Adobe PDF | View/Open |
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