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DC Field | Value | Language |
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dc.contributor.author | Rombauts, Alexander | - |
dc.contributor.author | Abelenda Alonso, Gabriela | - |
dc.contributor.author | Càmara, Jordi | - |
dc.contributor.author | Lorenzo Esteller, Laia | - |
dc.contributor.author | González-Díaz, Aida | - |
dc.contributor.author | Sastre Escolà, Enric | - |
dc.contributor.author | Gudiol González, Carlota | - |
dc.contributor.author | Dorca i Sargatal, Jordi | - |
dc.contributor.author | Tebé, Cristian | - |
dc.contributor.author | Pallarès, Natàlia | - |
dc.contributor.author | Ardanuy Tisaire, María Carmen | - |
dc.contributor.author | Carratalà, Jordi | - |
dc.date.accessioned | 2021-06-08T07:56:57Z | - |
dc.date.available | 2021-06-08T07:56:57Z | - |
dc.date.issued | 2020-10-26 | - |
dc.identifier.issn | 2328-8957 | - |
dc.identifier.uri | http://hdl.handle.net/2445/178090 | - |
dc.description.abstract | Background: Acute cardiac events (ACEs) are increasingly being recognized as a major complication in pneumococcal community-acquired pneumonia (CAP). Information regarding host- and pathogen-related factors for ACEs, including pneumococcal serotypes and clonal complexes, is scarce. Methods: A retrospective study was conducted of a prospective cohort of patients hospitalized for CAP between 1996 and 2019. Logistic regression and funnel plot analyses were performed to determine host- and pathogen-related factors for ACEs. Results: Of 1739 episodes of pneumococcal CAP, 1 or more ACEs occurred in 304 (17.5%) patients, the most frequent being arrhythmia (n = 207), heart failure (n = 135), and myocardial infarction (n = 23). The majority of ACEs (73.4%) occurred within 48 hours of admission. Factors independently associated with ACEs were older age, preexisting heart conditions, pneumococcal bacteremia, septic shock at admission, and high-risk pneumonia. Among 983 pneumococcal isolates, 872 (88.7%) were serotyped and 742 (75.5%) genotyped. The funnel plot analyses did not find any statistically significant association between serotypes or clonal complexes with ACEs. Nevertheless, there was a trend toward an association between CC230 and these complications. ACEs were independently associated with 30-day mortality (adjusted odds ratio, 1.88; 95% CI, 1.11-3.13). Conclusions: ACEs are frequent in pneumococcal pneumonia and are associated with increased mortality. The risk factors defined in this study may help identify patients who must undergo close follow-up, including heart rhythm monitoring, and special care to avoid fluid overload, particularly during the first 48 hours of admission. These high-risk patients should be the target for preventive intervention strategies. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/ofid/ofaa522 | - |
dc.relation.ispartof | Open Forum Infectious Diseases, 2020, vol. 7, num. 12 | - |
dc.relation.uri | https://doi.org/10.1093/ofid/ofaa522 | - |
dc.rights | cc-by-nc-nd (c) Rombauts, Alexander et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Pneumònia adquirida a la comunitat | - |
dc.subject.classification | Malalties del cor | - |
dc.subject.other | Community-acquired pneumonia | - |
dc.subject.other | Heart diseases | - |
dc.title | Host- and Pathogen-Related Factors for Acute Cardiac Events in Pneumococcal Pneumonia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 706887 | - |
dc.date.updated | 2021-06-08T07:56:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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706887.pdf | 520.57 kB | Adobe PDF | View/Open |
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