Please use this identifier to cite or link to this item:
Title: Tuberculosis infection in children visiting friends and relatives in countries with high incidence of tuberculosis: A study protocol
Author: Soriano Arandes, Antoni
Caylà i Buqueras, Joan A.
Queiroga Gonçalves, Alessandra
Orcau i Palau, Àngels
Noguera Julian, Antoni
Padilla, Emma
Solà Segura, Elisabet
Ríus Gordillo, Neus
Espiau, María
García Lerín, Mónica G.
Rifà Pujol, Maria Àngels
Gómez i Prat, Jordi
Macia Rieradevall, Esperança
Martín Nalda, Andrea
Eril Rius, Maria
Santos Santiago, José
Busquets Poblet, Lídia
Morales Martínez, Raisa
Pérez-Porcuna, Tomàs M.
Keywords: Tuberculosi
Infeccions en els infants
Infection in children
Issue Date: 4-Sep-2020
Publisher: Lippincott, Williams & Wilkins. Wolters Kluwer Health
Abstract: Introduction: Tuberculosis (TB) is a global infectious disease. In low-incidence countries, paediatric TB affects mostly immigrant children and children of immigrants. We hypothesize that these children are at risk of exposure to Mycobacterium tuberculosis when they travel to the country of origin of their parents to visit friends and relatives (VFR). In this study, we aim to estimate the incidence rate and risk factors associated to latent tuberculosis infection (LTBI) and TB in VFR children. Methods and analysis: A prospective study will be carried out in collaboration with 21 primary health care centres (PCC) and 5 hospitals in Catalonia, Spain. The study participants are children under 15 years of age, either immigrant themselves or born to immigrant parents, who travel to countries with high incidence of TB (≥ 40 cases/100,000 inhabitants). A sample size of 492 children was calculated. Participants will be recruited before traveling, either during a visit to a travel clinic or to their PCC, where a questionnaire including sociodemographic, epidemiological and clinical data will be completed, and a tuberculin skin test (TST) will be performed and read after 48 to 72 hours; patients with a positive TST at baseline will be excluded. A visit will be scheduled eight to twelve-weeks after their return to perform a TST and a QuantiFERON-TB Gold Plus test. The incidence rate of LTBI will be estimated per individual/month and person/year per country visited, and also by age-group.
Note: Reproducció del document publicat a:
It is part of: Medicine, 2020, vol. 99, num. 36, p. e22015
Related resource:
ISSN: 0025-7974
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

Files in This Item:
File Description SizeFormat 
703246.pdf311.88 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons