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DC Field | Value | Language |
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dc.contributor.author | Santín Cerezales, Miguel | - |
dc.contributor.author | Escrich, Cristina | - |
dc.contributor.author | Majòs, Carles | - |
dc.contributor.author | Llaberia, Mariona | - |
dc.contributor.author | Grijota, María D. | - |
dc.contributor.author | Grau, Imma | - |
dc.date.accessioned | 2021-06-08T08:17:32Z | - |
dc.date.available | 2021-06-08T08:17:32Z | - |
dc.date.issued | 2020-10-23 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | http://hdl.handle.net/2445/178095 | - |
dc.description.abstract | Rationale: Paradoxical reaction/immune reconstitution inflammatory syndrome is common in patients with central nervous system tuberculosis. Management relies on high-dose corticosteroids and surgery when feasible. Patient concern: We describe 2 cases of HIV-negative patients with corticosteroid-refractory paradoxical reactions of central nervous system tuberculosis. Diagnoses: The 2 patients experienced clinical impairment shortly after starting therapy for TB, and magnetic resonance imaging showed the presence of tuberculomas, leading to the diagnosis of a paradoxical reaction. Interventions: We added infliximab, an anti-tumor necrosis factor (TNF)-alpha monoclonal antibody, to the dexamethasone. Outcomes: Both patients had favorable outcomes, 1 achieving full recovery but 1 suffering neurologic sequelae. Lessons: Clinicians should be aware of the risk of paradoxical reactions/immune reconstitution inflammatory syndrome when treating patients with tuberculosis of the central nervous system and should consider the prompt anti-TNF-α agents in cases not responding to corticosteroids. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Lippincott, Williams & Wilkins. Wolters Kluwer Health | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1097/MD.0000000000022626 | - |
dc.relation.ispartof | Medicine, 2020, vol. 99, num. 43, p. e22626 | - |
dc.relation.uri | https://doi.org/10.1097/MD.0000000000022626 | - |
dc.rights | cc-by (c) Santín Cerezales, Miguel et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Tuberculosi | - |
dc.subject.classification | Inflamació | - |
dc.subject.other | Tuberculosis | - |
dc.subject.other | Inflammation | - |
dc.title | Tumor necrosis factor antagonists for paradoxical inflammatory reactions in the central nervous system tuberculosis: Case report and review | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 705422 | - |
dc.date.updated | 2021-06-08T08:17:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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705422.pdf | 542.09 kB | Adobe PDF | View/Open |
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