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Title: Human Translational Research in Psoriasis Using CLA+ T Cells
Author: Ruiz Romeu, Ester
Santamaria Babí, Luis F.
Keywords: Psoriasi
Issue Date: Jul-2017
Publisher: IntechOpen
Abstract: Focusing on the study of human memory CLA+ T cells to understand psoriasis pathology constitutes an innovative approach to explore the pathological mechanism of this chronic cutaneous inflammatory disease. CLA+ T cells can be considered peripheral cell biomarkers in the study of T-cell mediated human skin diseases. During the last few years, new evidences have been found that link streptococcal infection with IL-17 response in psoriasis by studying the interaction between Streptococcus pyogenes with CLA+ T cells and autologous epidermal cells. S. pyogenes constitutes the best clinically characterized trigger of psoriasis and by exploring its effect on CLA+ T cells and epidermal cells in psoriasis may allow understanding psoriasis by using patient’s clinical samples ex vivo.
Note: Reproducció del document publicat a:
It is part of: Chapter 4 in: Chiriac, Anca. 2017. Psoriasis. IntechOpen. ISBN: 978-953-51-4763-3. DOI: 10.5772/65196. pp: 62-74.
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Appears in Collections:Llibres / Capítols de llibre (Biologia Cel·lular, Fisiologia i Immunologia)

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