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Title: | Consumption of Ultra-Processed Food and Drinks and Chronic Lymphocytic Leukemia in the MCC-Spain Study |
Author: | Solans, Marta Fernández Barrés, Sílvia Romaguera, Dora Benavente, Yolanda Marcos Gragera, Rafael Gracia Lavedan, Esther Costas, Laura Robles, Claudia González Barca, Eva Banda, Esmeralda de la Alonso Sanz, Esther Aymerich Gregorio, Marta Campo Güerri, Elias Llorca, Javier Fernández Tardón, Guillermo Olmedo Requena, Rocío Gimeno, Eva Castaño-Vinyals, Gemma Aragonès Sanz, Núria Kogevinas, Manolis Pollán, Marina Sanjosé Llongueras, Silvia de Amiano, Pilar Casabonne, Delphine |
Keywords: | Leucèmia limfocítica crònica Càncer Estils de vida Chronic lymphocytic leukemia Cancer Lifestyles |
Issue Date: | 20-May-2021 |
Publisher: | MDPI |
Abstract: | Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. Its etiology is largely unknown but increasing incidence rates observed worldwide suggest that lifestyle and environmental factors such as diet might play a role in the development of CLL. Hence, we hypothesized that the consumption of ultra-processed food and drinks (UPF) might be associated with CLL. Data from a Spanish population-based case-control study (MCC-Spain study) including 230 CLL cases (recruited within three years of diagnosis) and 1634 population-based controls were used. The usual diet during the previous year was collected through a validated food frequency questionnaire and food and drink consumption was categorized using the NOVA classification scheme. Logistic regression models adjusted for potential confounders were used. Overall, no association was reported between the consumption of UPF and CLL cases (OR per each 10% increase of the relative contribution of UPF to total dietary intake = 1.09 (95% CI: 0.94; 1.25)), independently of the Rai stage at diagnosis. However, when analyses were restricted to cases diagnosed within <1 year (incident), each 10% increment in the consumption of UPF was associated with a 22% higher odds ratio of CLL (95% CI: 1.02, 1.47) suggesting that the overall results might be affected by the inclusion of prevalent cases, who might have changed their dietary habits after cancer diagnosis. Given the low number of cases in the subgroup analyses and multiple tests performed, chance findings cannot totally be ruled out. Nonetheless, positive associations found in CLL incident cases merit further research, ideally in well-powered studies with a prospective design. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijerph18105457 |
It is part of: | International Journal of Environmental Research and Public Health, 2021, vol. 18, num. 10, p. 5457 |
URI: | http://hdl.handle.net/2445/178236 |
Related resource: | https://doi.org/10.3390/ijerph18105457 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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