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http://hdl.handle.net/2445/178237
Title: | Severe infections and infection-related mortality in a large series of haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide |
Author: | Esquirol, Albert Pascual, Maria Jesús Kwon, Mi Pérez, Ariadna Parody, Rocío Ferra, Christelle García Cadenas, Irene Herruzo, Beatriz Dorado-Herrero, Nieves Hernani, Rafael Sánchez Ortega, Isabel Torrent, Anna Sierra, Jorge Martino, Rodrigo Spanish Group for Hematopoietic Stem cell Transplantation (GETH) |
Keywords: | Malalties hematològiques Malalties infeccioses Cèl·lules mare Hematologic diseases Communicable diseases Stem cells |
Issue Date: | 31-May-2021 |
Publisher: | Springer Nature |
Abstract: | Severe infections and their attributable mortality are major complications in recipients of allogeneic hematopoietic stem cell transplantation (alloSCT). We herein report 236 adult patients who received haploSCT with PTCy. The median follow-up for survivors was 37 months. The overall incidence of bloodstream infections by gram-positive and gram-negative bacteria at 37 months was 51% and 46%, respectively. The incidence of cytomegalovirus infection was 69%, while Epstein Barr virus infections occurred in 10% of patients and hemorrhagic cystitis in 35% of cases. Invasive fungal infections occurred in 11% at 17 months. The 3-year incidence of infection-related mortality was 19%. The median interval from transplant to IRM was 3 months (range 1-30), 53% of IRM occurred >100 days post-haploSCT. Risk factors for IRM included age >50 years, lymphoid malignancy, and developing grade III-IV acute GvHD. Bacterial infections were the most common causes of IRM (51%), mainly due to gram-negative bacilli BSI. In conclusion, severe infections are the most common causes of NRM after haploSCT with PTCy, with a reemergence of gram-negative bacilli as the most lethal pathogens. More studies focusing on the severe infections after haploSCT with PTCy and differences with other types of alloSCT in adults are clearly warranted. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41409-021-01328-4 |
It is part of: | Bone Marrow Transplantation, 2021 |
URI: | http://hdl.handle.net/2445/178237 |
Related resource: | https://doi.org/10.1038/s41409-021-01328-4 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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