Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/178238
Title: Memory and strategic processing in first-degree relatives of obsessive compulsive patients
Author: Segalàs Cosi, Cinto
Alonso, Pino
Real, Eva
García Ruiz de Gordejuela, Amador
Miñambres Donaire, Aitor
Labad, Javier
Pertusa, Alberto
Bueno, Blanca
Jiménez-Murcia, Susana
Menchón Magriñá, José Manuel
Keywords: Trastorns de la conducta
Genètica
Fisiologia
Patologia
Behavior disorders
Genetics
Physiology
Pathology
Issue Date: 1-Dec-2010
Publisher: Cambridge University Press
Abstract: Background: the same executive dysfunctions and alterations in neuroimaging tests (both functional and structural) have been found in obsessive-compulsive patients and their first-degree relatives. These neurobiological findings are considered to be intermediate markers of the disease. The aim of our study was to assess verbal and non-verbal memory in unaffected first-degree relatives, in order to determine whether these neuropsychological functions constitute a new cognitive marker for obsessive-compulsive disorder (OCD). Method: recall and use of organizational strategies in verbal and non-verbal memory tasks were measured in 25 obsessive-compulsive patients, 25 unaffected first-degree relatives and 25 healthy volunteers. Results: first-degree relatives and healthy volunteers did not show differences on most measures of verbal memory. However, during the recall and processing of non-verbal information, deficits were found in first-degree relatives and patients compared with healthy volunteers. Conclusions: the presence of the same deficits in the execution of non-verbal memory tasks in OCD patients and unaffected first-degree relatives suggests the influence of certain genetic and/or familial factors on this cognitive function in OCD and supports the hypothesis that deficits in non-verbal memory tasks could be considered as cognitive markers of the disorder.
Note: Reproducció del document publicat a: https://doi.org/10.1017/S0033291710000310
It is part of: Psychological Medicine, 2010, vol. 40, num. 12, p. 2001-2011
URI: http://hdl.handle.net/2445/178238
Related resource: https://doi.org/10.1017/S0033291710000310
ISSN: 0033-2917
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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