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http://hdl.handle.net/2445/178238
Title: | Memory and strategic processing in first-degree relatives of obsessive compulsive patients |
Author: | Segalàs Cosi, Cinto Alonso, Pino Real, Eva García Ruiz de Gordejuela, Amador Miñambres Donaire, Aitor Labad, Javier Pertusa, Alberto Bueno, Blanca Jiménez-Murcia, Susana Menchón Magriñá, José Manuel |
Keywords: | Trastorns de la conducta Genètica Fisiologia Patologia Behavior disorders Genetics Physiology Pathology |
Issue Date: | 1-Dec-2010 |
Publisher: | Cambridge University Press |
Abstract: | Background: the same executive dysfunctions and alterations in neuroimaging tests (both functional and structural) have been found in obsessive-compulsive patients and their first-degree relatives. These neurobiological findings are considered to be intermediate markers of the disease. The aim of our study was to assess verbal and non-verbal memory in unaffected first-degree relatives, in order to determine whether these neuropsychological functions constitute a new cognitive marker for obsessive-compulsive disorder (OCD). Method: recall and use of organizational strategies in verbal and non-verbal memory tasks were measured in 25 obsessive-compulsive patients, 25 unaffected first-degree relatives and 25 healthy volunteers. Results: first-degree relatives and healthy volunteers did not show differences on most measures of verbal memory. However, during the recall and processing of non-verbal information, deficits were found in first-degree relatives and patients compared with healthy volunteers. Conclusions: the presence of the same deficits in the execution of non-verbal memory tasks in OCD patients and unaffected first-degree relatives suggests the influence of certain genetic and/or familial factors on this cognitive function in OCD and supports the hypothesis that deficits in non-verbal memory tasks could be considered as cognitive markers of the disorder. |
Note: | Reproducció del document publicat a: https://doi.org/10.1017/S0033291710000310 |
It is part of: | Psychological Medicine, 2010, vol. 40, num. 12, p. 2001-2011 |
URI: | http://hdl.handle.net/2445/178238 |
Related resource: | https://doi.org/10.1017/S0033291710000310 |
ISSN: | 0033-2917 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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