Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/178258
Title: | Aberrant Synaptic PTEN in Symptomatic Alzheimer’s Patients May Link Synaptic Depression to Network Failure |
Author: | Díaz González, Marta Buberman, Assaf Morales, Miguel Ferrer, Isidro (Ferrer Abizanda) Knafo, Shira |
Keywords: | Malaltia d'Alzheimer Hipocamp (Cervell) Cognició Alzheimer's disease Hippocampus (Brain) Cognition |
Issue Date: | 11-May-2021 |
Publisher: | Frontiers Media S. A. |
Abstract: | In Alzheimer's disease (AD), Amyloid β (Aβ) impairs synaptic function by inhibiting long-term potentiation (LTP), and by facilitating long-term depression (LTD). There is now evidence from AD models that Aβ provokes this shift toward synaptic depression by triggering the access to and accumulation of PTEN in the postsynaptic terminal of hippocampal neurons. Here we quantified the PTEN in 196,138 individual excitatory dentate gyrus synapses from AD patients at different stages of the disease and from controls with no neuropathological findings. We detected a gradual increase of synaptic PTEN in AD brains as the disease progresses, in conjunction with a significant decrease in synaptic density. The synapses that remain in symptomatic AD patients are more likely to be smaller and exhibit fewer AMPA receptors (AMPARs). Hence, a high Aβ load appears to strongly compromise human hippocampal synapses, as reflected by an increase in PTEN, inducing a loss of AMPARs that may eventually provoke synaptic failure and loss. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fnsyn.2021.683290 |
It is part of: | Frontiers in Synaptic Neuroscience, 2021, vol. 13 |
URI: | http://hdl.handle.net/2445/178258 |
Related resource: | https://doi.org/10.3389/fnsyn.2021.683290 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
fnsyn-13-683290.pdf | 6.93 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License