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Title: | Health and economic impact of the correct diagnosis of transthyretin cardiac amyloidosis in Spain |
Author: | Formiga Pérez, Francesc Garcia Pavia, Pablo Martín Sánchez, Francisco Javier Navarro-Ruiz, Andrés Rubio-Terrés, Carlos Peral, Carmen Tarilonte, Patricia López-Ibáñez de Aldecoa, Alejandra Rubio-Rodríguez, Darío |
Keywords: | Amiloïdosi Diagnòstic Espanya Amyloidosis Diagnosis Spain |
Issue Date: | 11-Jun-2011 |
Publisher: | Informa Healthcare |
Abstract: | Objective: to estimate the health and economic impact of the reduction in mortality and cardiovascular hospitalizations, associated with correct diagnosis of cardiac transthyretin amyloidosis (ATTR-CM), from the Spanish National Health System (NHS) perspective. Methods: a costs and effects analysis were performed (probabilistic Markov model) with time horizons between 1 and 15 years, comparing the correct diagnosis of ATTR-CM versus the non-diagnosis. Transition probabilities were obtained from the ATTR-ACT study (placebo arm) and from the literature. Costs and healthcare resources were obtained from Spanish sources ( 2019) and from a panel of Spanish clinical experts. Results: after 1, 5, 10 and 15 years, the diagnosis of ATTR-CM would generate a gain of 0.031 (95%CI 0.025; 0.038); 0.387 (95%CI 0.329; 0.435); 0.754 (95%CI 0.678; 0.781) and 0.944 (95%CI 0.905; 0.983) life years per patient, respectively, with savings of 212 (95%CI -632; 633), 2,289 (95%CI 2,250; 2,517), 2,859 (95%CI 2,584; 3,149) and 2,906 (95%CI 2,669; 3,450) per patient, respectively, versus the non-diagnosis. Conclusions: just by correctly diagnosing ATTR-CM, years of life would be gained, cardiovascular hospitalizations would be avoided, and savings would be generated for the NHS, compared to the non-diagnosis of the disease. |
Note: | Reproducció del document publicat a: https://doi.org/10.1080/14737167.2021.1933948 |
It is part of: | Expert Review of Pharmacoeconomics & Outcomes Research, 2011, vol. 11, p. 1-7 |
URI: | http://hdl.handle.net/2445/178415 |
Related resource: | https://doi.org/10.1080/14737167.2021.1933948 |
ISSN: | 1473-7167 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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712753.pdf | 1 MB | Adobe PDF | View/Open |
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