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Title: | Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis |
Author: | Cano Jiménez, Esteban Vázquez Rodríguez, Tomás Martín Robles, Irene Castillo Villegas, Diego Juan García, Javier Bollo de Miguel, Elena Robles-Pérez, Alejandro Ferrer Galván, Marta Mouronte Roibas, Cecilia Herrera Lara, Susana Bermudo, Guadalupe García Moyano, Marta Rodríguez Portal, Jose Antonio Sellarés, Jacobo Narváez, Javier Molina Molina, María |
Keywords: | Malalties del pulmó Artritis reumatoide Mortalitat Pulmonary diseases Rheumatoid arthritis Mortality |
Issue Date: | 28-Apr-2021 |
Publisher: | Springer Nature |
Abstract: | Rheumatoid arthritis (RA) is a systemic autoimmune disease whose main extra-articular organ affected is the lung, sometimes in the form of diffuse interstitial lung disease (ILD) and conditions the prognosis. A multicenter, observational, descriptive and cross-sectional study of consecutive patients diagnosed with RA-ILD. Demographic, analytical, respiratory functional and evolution characteristics were analyzed to evaluate the predictors of progression and mortality. 106 patients were included. The multivariate analysis showed that the diagnostic delay was an independent predictor of mortality (HR 1.11, CI 1.01-1.23, p = 0.035). Also, age (HR 1.33, 95% CI 1.09-1.62, p = 0.0045), DLCO (%) (HR 0.85, 95% CI 0.73-0.98, p = 0.0246), and final SatO2 (%) in the 6MWT (HR 0.62, 95% CI 0.39-0.99, p = 0.0465) were independent predictor variables of mortality, as well as GAP index (HR 4.65, 95% CI 1.59-13.54, p = 0.0051) and CPI index (HR 1.12, 95% CI 1.03-1.22, p = 0.0092). The withdrawal of MTX or LFN after ILD diagnosis was associated with disease progression in the COX analysis (HR 2.18, 95% CI 1.14-4.18, p = 0.019). This is the first study that highlights the diagnostic delay in RA-ILD is associated with an increased mortality just like happens in IPF. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-88734-2 |
It is part of: | Scientific Reports, 2021, vol. 11 |
URI: | http://hdl.handle.net/2445/178514 |
Related resource: | https://doi.org/10.1038/s41598-021-88734-2 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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s41598-021-88734-2.pdf | 1.98 MB | Adobe PDF | View/Open |
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