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http://hdl.handle.net/2445/178537
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DC Field | Value | Language |
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dc.contributor.author | Vincenti, Flavio | - |
dc.contributor.author | Rostaing, Lionel | - |
dc.contributor.author | Grinyó Boira, Josep M. | - |
dc.contributor.author | Rice, Kim | - |
dc.contributor.author | Steinberg, Steven | - |
dc.contributor.author | Gaite, Luis | - |
dc.contributor.author | Moal, Marie-Christine | - |
dc.contributor.author | Mondragon-Ramírez, Guillermo A. | - |
dc.contributor.author | Kothari, Jatin | - |
dc.contributor.author | Polinsky, Martin S. | - |
dc.contributor.author | Meier-Kriesche, Herwig-Ulf | - |
dc.contributor.author | Munier, Stephane | - |
dc.contributor.author | Larsen, Christian P. | - |
dc.date.accessioned | 2021-06-17T16:18:59Z | - |
dc.date.available | 2021-06-17T16:18:59Z | - |
dc.date.issued | 2016-01-28 | - |
dc.identifier.issn | 0028-4793 | - |
dc.identifier.uri | http://hdl.handle.net/2445/178537 | - |
dc.description.abstract | Background: in previous analyses of BENEFIT, a phase 3 study, belatacept-based immunosuppression, as compared with cyclosporine-based immunosuppression, was associated with similar patient and graft survival and significantly improved renal function in kidney-transplant recipients. Here we present the final results from this study. Methods: we randomly assigned kidney-transplant recipients to a more-intensive belatacept regimen, a less-intensive belatacept regimen, or a cyclosporine regimen. Efficacy and safety outcomes for all patients who underwent randomization and transplantation were analyzed at year 7 (month 84). Results: a total of 666 participants were randomly assigned to a study group and underwent transplantation. Of the 660 patients who were treated, 153 of the 219 patients treated with the more-intensive belatacept regimen, 163 of the 226 treated with the less-intensive belatacept regimen, and 131 of the 215 treated with the cyclosporine regimen were followed for the full 84-month period; all available data were used in the analysis. A 43% reduction in the risk of death or graft loss was observed for both the more-intensive and the less-intensive belatacept regimens as compared with the cyclosporine regimen (hazard ratio with the more-intensive regimen, 0.57; 95% confidence interval [CI], 0.35 to 0.95; P=0.02; hazard ratio with the less-intensive regimen, 0.57; 95% CI, 0.35 to 0.94; P=0.02), with equal contributions from the lower rates of death and graft loss. The mean estimated glomerular filtration rate (eGFR) increased over the 7-year period with both belatacept regimens but declined with the cyclosporine regimen. The cumulative frequencies of serious adverse events at month 84 were similar across treatment groups. Conclusions: seven years after transplantation, patient and graft survival and the mean eGFR were significantly higher with belatacept (both the more-intensive regimen and the less-intensive regimen) than with cyclosporine. (Funded by Bristol-Myers Squibb; ClinicalTrials.gov number, NCT00256750). | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Massachusetts Medical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1056/NEJMoa1506027 | - |
dc.relation.ispartof | New England Journal of Medicine, 2016, vol. 374, num. 4, p. 333-343 | - |
dc.relation.uri | https://doi.org/10.1056/NEJMoa1506027 | - |
dc.rights | (c) Massachusetts Medical Society, 2016 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Ciclosporina | - |
dc.subject.classification | Ronyó | - |
dc.subject.classification | Rebuig (Biologia) | - |
dc.subject.classification | Cirurgia | - |
dc.subject.other | Cyclosporine | - |
dc.subject.other | Kidney | - |
dc.subject.other | Graft rejection | - |
dc.subject.other | Surgery | - |
dc.title | Belatacept and long-term outcomes in kidney transplantation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 666636 | - |
dc.date.updated | 2021-06-17T16:18:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26816011 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
Files in This Item:
File | Description | Size | Format | |
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666636.pdf | 626.46 kB | Adobe PDF | View/Open |
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