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DC Field | Value | Language |
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dc.contributor.author | Moura, David S. | - |
dc.contributor.author | Ramos, Rafel | - |
dc.contributor.author | Fernandez-Serra, Antonio | - |
dc.contributor.author | Serrano Piñol, M. Teresa | - |
dc.contributor.author | Cruz, Julia | - |
dc.contributor.author | Alvarez-Alegret, Ramiro | - |
dc.contributor.author | Ortiz-Duran, Rosa | - |
dc.contributor.author | Vicioso, Luis | - |
dc.contributor.author | Gomez-Dorronsoro, Maria Luisa | - |
dc.contributor.author | García del Muro Solans, Xavier | - |
dc.contributor.author | Martinez-Trufero, Javier | - |
dc.contributor.author | Rubió Casadevall, Jordi | - |
dc.contributor.author | Sevilla, Isabel | - |
dc.contributor.author | Lainez, Nuria | - |
dc.contributor.author | Gutiérrez, Antonio | - |
dc.contributor.author | Serrano, César | - |
dc.contributor.author | Lopez-Alvarez, Maria | - |
dc.contributor.author | Hindi, Nadia | - |
dc.contributor.author | Taron, Miquel | - |
dc.contributor.author | López Guerrero, José Antonio | - |
dc.contributor.author | Martin-Broto, Javier | - |
dc.date.accessioned | 2021-06-21T17:42:33Z | - |
dc.date.available | 2021-06-21T17:42:33Z | - |
dc.date.issued | 2018-04-03 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | http://hdl.handle.net/2445/178609 | - |
dc.description.abstract | Introduction: there are limited findings available on KIT-negative GIST-like (KNGL) population. Also, KIT expression may be post-transcriptionally regulated by miRNA221 and miRNA222. Hence, the aim of this study is to characterize KNGL population, by differential gene expression, and to analyze miRNA221/222 expression and their prognostic value in KNGL patients. Methods: KIT, PDGFRA, DOG1, IGF1R, MIR221 and MIR222 expression levels were determined by qRT-PCR. We also analyzed KIT and PDGFRA mutations, DOG1 expression, by immunohistochemistry, along with clinical and pathological data. Disease-free survival (DFS) and overall survival (OS) differences were calculated using Log-rank test. Results: hierarchical cluster analyses from gene expression data identified two groups: group I had KIT, DOG1 and PDGFRA overexpression and IGF1R underexpression and group II had overexpression of IGF1R and low expression of KIT, DOG1 and PDGFRA. Group II had a significant worse OS (p = 0.013) in all the series, and showed a tendency for worse OS (p = 0.11), when analyzed only the localized cases. MiRNA222 expression was significantly lower in a control subset of KIT-positive GIST (p < 0.001). OS was significantly worse in KNGL cases with higher expression of MIR221 (p = 0.028) or MIR222 (p = 0.014). Conclusions: we identified two distinct KNGL subsets, with a different prognostic value. Increased levels of miRNA221/222, which are associated with worse OS, could explain the absence of KIT protein expression of most KNGL tumors. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Impact Journals | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.24799 | - |
dc.relation.ispartof | Oncotarget, 2018, vol. 9, num. 25, p. 17576-17588 | - |
dc.relation.uri | https://doi.org/10.18632/oncotarget.24799 | - |
dc.rights | cc-by (c) Moura, David S. et al., 2018 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | RNA | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.classification | Pacients | - |
dc.subject.other | RNA | - |
dc.subject.other | Gene expression | - |
dc.subject.other | Patients | - |
dc.title | Gene expression analyses determine two different subpopulations in KIT-negative GIST-like (KNGL) patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 688187 | - |
dc.date.updated | 2021-06-21T17:42:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29707131 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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688187.pdf | 1.31 MB | Adobe PDF | View/Open |
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