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http://hdl.handle.net/2445/178638
Title: | Caveolin-1 in sarcomas: friend or foe? |
Author: | Sáinz Jaspeado, Miguel Guillermo Martín Liberal, Juan Jesús Lagares Tena, Laura Mateo Lozano, Silvia García del Muro Solans, Xavier Tirado, Oscar M. |
Keywords: | Fisiologia Sarcoma Diagnòstic Etiologia Physiology Sarcoma Diagnosis Etiology |
Issue Date: | 1-Apr-2011 |
Publisher: | Impact Journals |
Abstract: | Sarcomas represent a heterogeneous group of tumors with a complex and difficult reproducible classification. Their pathogenesis is poorly understood and there are few effective treatment options for advanced disease. Caveolin-1 is a multifunctional scaffolding protein with multiple binding partners that regulates multiple cancer-associated processes including cellular transformation, tumor growth, cell death and survival, multidrug resistance, angiogenesis, cell migration and metastasis. However, ambiguous roles have been ascribed to caveolin-1 in signal transduction and cancer, including sarcomas. In particular, evidence indicating that caveolin-1 function is cell context dependent has been repeatedly reported. Caveolin-1 appears to act as a tumor suppressor protein at early stages of cancer progression. In contrast, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. This review is focused on the role of caveolin-1 in several soft tissue and bone sarcomas and discusses the use of this protein as a potential diagnostic and prognostic marker and as a therapeutic target. |
Note: | Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.255 |
It is part of: | Oncotarget, 2011, vol. 2, num. 4, p. 305-312 |
URI: | http://hdl.handle.net/2445/178638 |
Related resource: | https://doi.org/10.18632/oncotarget.255 |
ISSN: | 1949-2553 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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