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http://hdl.handle.net/2445/178786
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DC Field | Value | Language |
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dc.contributor.author | Lakeman, Inge M. M. | - |
dc.contributor.author | Van Den Broek, Alexandra J. | - |
dc.contributor.author | Vos, Juliën A. M. | - |
dc.contributor.author | Barnes, Daniel R. | - |
dc.contributor.author | Adlard, Julian | - |
dc.contributor.author | Andrulis, Irene L. | - |
dc.contributor.author | Arason, Adalgeir | - |
dc.contributor.author | Arnold, Norbert | - |
dc.contributor.author | Arun, Banu K. | - |
dc.contributor.author | Balmaña, Judith | - |
dc.contributor.author | Barrowdale, Daniel | - |
dc.contributor.author | Mcguffog, Lesley | - |
dc.contributor.author | Miller, Austin | - |
dc.contributor.author | Coupier, Isabelle | - |
dc.contributor.author | Gomes, Denise Molina | - |
dc.contributor.author | Risch, Harvey A. | - |
dc.contributor.author | Barouk Simonet, Emmanuelle | - |
dc.contributor.author | Montagna, Marco | - |
dc.contributor.author | Miller, Clare | - |
dc.contributor.author | Elan, Camille | - |
dc.contributor.author | Hanson, Helen | - |
dc.contributor.author | Walker, Lisa | - |
dc.contributor.author | Davidson, Rosemarie | - |
dc.contributor.author | Mouret Fourme, Emmanuelle | - |
dc.contributor.author | Gayther, Simon A. | - |
dc.contributor.author | Nathanson, Katherine L. | - |
dc.contributor.author | Neuhausen, Susan L. | - |
dc.contributor.author | Nevanlinna, Heli | - |
dc.contributor.author | Lasset, Christine | - |
dc.contributor.author | Yie, Joanne Ngeow Yuen | - |
dc.contributor.author | Pauw, Antoine de | - |
dc.contributor.author | Olah, Edith | - |
dc.contributor.author | Collée, J. Margriet | - |
dc.contributor.author | Hooning, Maartje J. | - |
dc.contributor.author | Morrison, Patrick J. | - |
dc.contributor.author | Olopade, Olufunmilayo I. | - |
dc.contributor.author | Van Asperen, Christi J. | - |
dc.contributor.author | Park, Sue K. | - |
dc.contributor.author | Parsons, Michael T. | - |
dc.contributor.author | Donaldson, Alan | - |
dc.contributor.author | Belotti, Muriel | - |
dc.contributor.author | Laurent, Maïté | - |
dc.contributor.author | Peterlongo, Paolo | - |
dc.contributor.author | Jakubowska, Anna | - |
dc.contributor.author | Stadler, Zsofia K. | - |
dc.contributor.author | Kriege, Mieke | - |
dc.contributor.author | Stoppa Lyonnet, Dominique | - |
dc.contributor.author | Sutter, Christian | - |
dc.contributor.author | Ong, Kai Ren | - |
dc.contributor.author | Delnatte, Capucine | - |
dc.contributor.author | Tan, Yen Yen | - |
dc.contributor.author | Toland, Amanda E. | - |
dc.contributor.author | Tung, Nadine | - |
dc.contributor.author | Van Rensburg, Elizabeth J. | - |
dc.contributor.author | Couch, Fergus J. | - |
dc.contributor.author | Spurdle, Amanda B. | - |
dc.contributor.author | Vega, Ana | - |
dc.contributor.author | Godwin, Andrew K. | - |
dc.contributor.author | Easton, Douglas F. | - |
dc.contributor.author | Bonadona, Valérie | - |
dc.contributor.author | Rookus, Matti A. | - |
dc.contributor.author | Chenevix-Trench, Georgia | - |
dc.contributor.author | Antoniou, Antonis C. | - |
dc.contributor.author | O’shaughnessy Kirwan, Aoife | - |
dc.contributor.author | Robson, Mark | - |
dc.contributor.author | Hahnen, Eric | - |
dc.contributor.author | Eccles, Diana | - |
dc.contributor.author | Schmidt, Marjanka K. | - |
dc.contributor.author | Meijers Heijboer, Hanne E. J. | - |
dc.contributor.author | Hopper, John L. | - |
dc.contributor.author | Adank, Muriel A. | - |
dc.contributor.author | Gemo Study Collaborators | - |
dc.contributor.author | Phillips, Kelly Anne | - |
dc.contributor.author | Embrace Collaborators | - |
dc.contributor.author | Ocgn Investigators | - |
dc.contributor.author | Goldgar, David E. | - |
dc.contributor.author | Daly, Mary B. | - |
dc.contributor.author | Hebon Investigators | - |
dc.contributor.author | Perkins, Jo | - |
dc.contributor.author | Kconfab Investigators | - |
dc.contributor.author | Schmutzler, Rita K. | - |
dc.contributor.author | Bressac de Paillerets, Brigitte | - |
dc.contributor.author | Kets, Carolien M. | - |
dc.contributor.author | Buecher, Bruno | - |
dc.contributor.author | Caputo, Sandrine M. | - |
dc.contributor.author | Ausems, Margreet G. E. M. | - |
dc.contributor.author | Gregory, Helen | - |
dc.contributor.author | Dennis, Joe | - |
dc.contributor.author | Caron, Olivier | - |
dc.contributor.author | Faivre, Laurence | - |
dc.contributor.author | Fert Ferrer, Sandra | - |
dc.contributor.author | Gauthier Villars, Marion | - |
dc.contributor.author | Mensenkamp, Arjen R. | - |
dc.contributor.author | Radice, Paolo | - |
dc.contributor.author | Gesta, Paul | - |
dc.contributor.author | Leroux, Dominique | - |
dc.contributor.author | Longy, Michel | - |
dc.contributor.author | Mari, Véronique | - |
dc.contributor.author | Teo, Soo Hwang | - |
dc.contributor.author | Mazoyer, Sylvie | - |
dc.contributor.author | Mebirouk, Noura | - |
dc.contributor.author | Mortemousque, Isabelle | - |
dc.contributor.author | Blok, Marinus J. | - |
dc.contributor.author | Prieur, Fabienne | - |
dc.contributor.author | Dunning, Alison M. | - |
dc.contributor.author | Hamann, Ute | - |
dc.contributor.author | Pujol, Pascal | - |
dc.contributor.author | Konstantopoulou, Irene | - |
dc.contributor.author | Heemskerk Gerritsen, Bernadette A. M. | - |
dc.contributor.author | Jensen, Uffe Birk | - |
dc.contributor.author | Isaacs, Claudine | - |
dc.contributor.author | Saule, Claire | - |
dc.contributor.author | Piedmonte, Marion | - |
dc.contributor.author | Schuster, Helene | - |
dc.contributor.author | Sevenet, Nicolas | - |
dc.contributor.author | Sobol, Hagay | - |
dc.contributor.author | Mooij, Thea M. | - |
dc.contributor.author | Sokolowska, Johanna | - |
dc.contributor.author | Gómez Garcia, Encarna B. | - |
dc.contributor.author | Venat Bouvet, Laurence | - |
dc.contributor.author | Singer, Christian F. | - |
dc.contributor.author | Claes, Kathleen B. M. | - |
dc.contributor.author | Ahmed, Munaza | - |
dc.contributor.author | Teixeira, Manuel R. | - |
dc.contributor.author | Barwell, Julian | - |
dc.contributor.author | Brady, Angela | - |
dc.contributor.author | Izatt, Louise | - |
dc.contributor.author | Hogervorst, Frans B. L. | - |
dc.contributor.author | Oosterwijk, Jan C. | - |
dc.contributor.author | Brennan, Paul | - |
dc.contributor.author | Harrington, Patricia A. | - |
dc.contributor.author | Wappenschmidt, Barbara | - |
dc.contributor.author | Henderson, Alex | - |
dc.contributor.author | Hodgson, Shirley | - |
dc.contributor.author | Kwong, Ava | - |
dc.contributor.author | Borg, Ake | - |
dc.contributor.author | Kennedy, M. John | - |
dc.contributor.author | Porteous, Mary E. | - |
dc.contributor.author | Rogers, Mark T. | - |
dc.contributor.author | Side, Lucy E. | - |
dc.contributor.author | Caux Moncoutier, Virginie | - |
dc.contributor.author | Snape, Katie | - |
dc.contributor.author | Rantala, Johanna | - |
dc.contributor.author | Dhawan, Mallika | - |
dc.contributor.author | Benitez, Javier | - |
dc.contributor.author | Domchek, Susan M. | - |
dc.contributor.author | Eeles, Rosalind A. | - |
dc.contributor.author | Engel, Christoph | - |
dc.contributor.author | Legrand, Clémentine | - |
dc.contributor.author | Evans, D. Gareth | - |
dc.contributor.author | James, Paul A. | - |
dc.contributor.author | Feliubadaló i Elorza, Maria Lídia | - |
dc.contributor.author | Devilee, Peter | - |
dc.contributor.author | Berthet, Pascaline | - |
dc.contributor.author | Teulé-Vega, Àlex | - |
dc.contributor.author | Foretova, Lenka | - |
dc.contributor.author | Castera, Laurent | - |
dc.contributor.author | Friedman, Eitan | - |
dc.contributor.author | Frost, Debra | - |
dc.contributor.author | Rennert, Gad | - |
dc.contributor.author | Ganz, Patricia A. | - |
dc.contributor.author | Leslie, Goska | - |
dc.contributor.author | Garber, Judy | - |
dc.contributor.author | Eason, Jacqueline | - |
dc.contributor.author | Hulick, Peter J. | - |
dc.contributor.author | Giraud, Sophie | - |
dc.contributor.author | Imyanitov, Evgeny N. | - |
dc.contributor.author | Glendon, Gord | - |
dc.contributor.author | Thomassen, Mads | - |
dc.contributor.author | Janavicius, Ramunas | - |
dc.contributor.author | Mulligan, Anna Marie | - |
dc.contributor.author | Hollestelle, Antoinette | - |
dc.contributor.author | Jager, Agnes | - |
dc.contributor.author | Koppert, Linetta B. | - |
dc.contributor.author | Van Asperen, Christi J. | - |
dc.contributor.author | Cook, Jackie | - |
dc.contributor.author | Koudijs, Marco | - |
dc.contributor.author | Caldés, Trinidad | - |
dc.contributor.author | Van den Ouweland, Ans M. W. | - |
dc.contributor.author | Van der Baan, Frederieke H. | - |
dc.contributor.author | Van der Hout, Annemieke H. | - |
dc.contributor.author | Van der Kolk, Lizet E. | - |
dc.contributor.author | Van der Luijt, Rob B. | - |
dc.contributor.author | Thull, Darcy L. | - |
dc.contributor.author | Van Deurzen, Carolien H. M. | - |
dc.contributor.author | Chung, Wendy K. | - |
dc.contributor.author | Sharma, Priyanka | - |
dc.contributor.author | Van Doorn, Helena C. | - |
dc.contributor.author | Golmard, Lisa | - |
dc.contributor.author | Bignon, Yves Jean | - |
dc.contributor.author | Colas, Chrystelle | - |
dc.contributor.author | Van Engelen, Klaartje | - |
dc.contributor.author | Brewer, Carole | - |
dc.contributor.author | Van Hest, Liselotte P. | - |
dc.contributor.author | Van Os, Theo A. M. | - |
dc.contributor.author | Caligo, Maria A. | - |
dc.contributor.author | Bernstein, Jonine L. | - |
dc.contributor.author | Verhoef, Senno | - |
dc.contributor.author | Tischkowitz, Marc | - |
dc.contributor.author | Vogel, Maartje J. | - |
dc.contributor.author | Hake, Christopher R. | - |
dc.contributor.author | Wijnen, Juul T. | - |
dc.contributor.author | Lalloo, Fiona | - |
dc.contributor.author | Beesley, Jonathan | - |
dc.contributor.author | Fox, Stephen | - |
dc.contributor.author | Collonge Rame, Marie Agnès | - |
dc.contributor.author | Simard, Jacques | - |
dc.contributor.author | Offit, Kenneth | - |
dc.contributor.author | Holland, Helene | - |
dc.contributor.author | Jiao, Yue | - |
dc.contributor.author | John, Esther M. | - |
dc.contributor.author | Joseph, Vijai | - |
dc.contributor.author | Houdayer, Claude | - |
dc.contributor.author | Gerdes, Anne Marie | - |
dc.contributor.author | Karlan, Beth Y. | - |
dc.contributor.author | Lesueur, Fabienne | - |
dc.contributor.author | Loud, Jennifer T. | - |
dc.contributor.author | Lubiński, Jan | - |
dc.contributor.author | Aalfs, Cora M. | - |
dc.contributor.author | Manoukian, Siranoush | - |
dc.date.accessioned | 2021-07-05T11:03:25Z | - |
dc.date.available | 2021-07-05T11:03:25Z | - |
dc.date.issued | 2021-06-10 | - |
dc.identifier.uri | http://hdl.handle.net/2445/178786 | - |
dc.description.abstract | Purpose: To evaluate the association between a previously published 313 variant-based breast cancer (BC) polygenic risk score (PRS313) and contralateral breast cancer (CBC) risk, in BRCA1 and BRCA2 pathogenic variant heterozygotes. Methods: We included women of European ancestry with a prevalent first primary invasive BC (BRCA1 = 6,591 with 1,402 prevalent CBC cases; BRCA2 = 4,208 with 647 prevalent CBC cases) from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), a large international retrospective series. Cox regression analysis was performed to assess the association between overall and ER-specific PRS313 and CBC risk. Results: For BRCA1 heterozygotes the estrogen receptor (ER)-negative PRS313 showed the largest association with CBC risk, hazard ratio (HR) per SD = 1.12, 95% confidence interval (CI) (1.06-1.18), C-index = 0.53; for BRCA2 heterozygotes, this was the ER-positive PRS313, HR = 1.15, 95% CI (1.07-1.25), C-index = 0.57. Adjusting for family history, age at diagnosis, treatment, or pathological characteristics for the first BC did not change association effect sizes. For women developing first BC < age 40 years, the cumulative PRS313 5th and 95th percentile 10-year CBC risks were 22% and 32% for BRCA1 and 13% and 23% for BRCA2 heterozygotes, respectively. Conclusion: The PRS313 can be used to refine individual CBC risks for BRCA1/2 heterozygotes of European ancestry, however the PRS313 needs to be considered in the context of a multifactorial risk model to evaluate whether it might influence clinical decision-making. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41436-021-01198-7 | - |
dc.relation.ispartof | Genetics in Medicine, 2021 | - |
dc.relation.uri | https://doi.org/10.1038/s41436-021-01198-7 | - |
dc.rights | cc by (c) Lakeman, Inge M. M. et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Risk factors in diseases | - |
dc.title | The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant | - |
dc.type | info:eu-repo/semantics/article | - |
dc.date.updated | 2021-07-02T12:34:01Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34113011 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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s41436-021-01198-7.pdf | 1.53 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License