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http://hdl.handle.net/2445/178837
Title: | Cellular Senescence in Lung Fibrosis |
Author: | Hernández-González, Fernanda Faner, Rosa Rojas, Mauricio Agustí García-Navarro, Àlvar Serrano, Manuel Sellarés, Jacobo |
Keywords: | Fibrosi pulmonar Envelliment Pulmonary fibrosis Aging |
Issue Date: | 29-Jun-2021 |
Publisher: | MDPI AG |
Abstract: | Fibrosing interstitial lung diseases (ILDs) are chronic and ultimately fatal age-related lung diseases characterized by the progressive and irreversible accumulation of scar tissue in the lung parenchyma. Over the past years, significant progress has been made in our incomplete understanding of the pathobiology underlying fibrosing ILDs, in particular in relation to diverse age-related processes and cell perturbations that seem to lead to maladaptation to stress and susceptibility to lung fibrosis. Growing evidence suggests that a specific biological phenomenon known as cellular senescence plays an important role in the initiation and progression of pulmonary fibrosis. Cellular senescence is defined as a cell fate decision caused by the accumulation of unrepairable cellular damage and is characterized by an abundant pro-inflammatory and pro-fibrotic secretome. The senescence response has been widely recognized as a beneficial physiological mechanism during development and in tumour suppression. However, recent evidence strengthens the idea that it also drives degenerative processes such as lung fibrosis, most likely by promoting molecular and cellular changes in chronic fibrosing processes. Here, we review how cellular senescence may contribute to lung fibrosis pathobiology, and we highlight current and emerging therapeutic approaches to treat fibrosing ILDs by targeting cellular senescence. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms22137012 |
It is part of: | International Journal of Molecular Sciences, 2021, vol. 22, num.13, p. 7012 |
URI: | http://hdl.handle.net/2445/178837 |
Related resource: | https://doi.org/10.3390/ijms22137012 |
ISSN: | 1422-0067 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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