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Title: Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience.
Author: Mozas, Pablo
Nadeu, Ferran
Rivas Delgado, Alfredo
Rivero, Andrea
Garrote, Marta
Balagué Ponz, Olga
González Farré, Blanca
Veloza, Luis
Baumann, Tycho
Giné Soca, Eva
Delgado, Julio (Delgado González)
Villamor i Casas, Neus
Campo Güerri, Elias
Magnano, Laura
López Guillermo, Armando
Keywords: Immunoteràpia
Issue Date: 5-Mar-2020
Publisher: Springer Nature
Abstract: Although the introduction of immunotherapy has improved outcomes for follicular lymphoma (FL) patients, histological transformation (HT) and early relapse still confer a poor prognosis. We sought to describe the patterns of change in treatment, response, and outcome of FL patients at our institution over the last four decades. Seven hundred and twenty-seven patients (389 F/338 M; median age, 57 years) consecutively diagnosed with grade 1-3a FL between 1980 and 2017, categorized into four decades according to the time of diagnosis, constituted the study population. Clinical characteristics, treatment, response, absolute and relative survival, HT, second malignancies (SM), and causes of death were assessed. Median OS for the entire cohort was 17.6 years. From decade 1 to 4, there was an increase in the complete response rate (48 to 70%), progression-free survival (40 to 56% at 5 years), OS (77 to 86% at 5 years), and relative survival ratio (0.83 to 0.94 at 5 years), with no significant differences in the risk of HT or SM. Lymphoma remained the most common cause of death in all four decades. These findings illustrate the overall improvement in outcome for FL patients, but support the need for further research into risk stratification and management.
Note: Reproducció del document publicat a:
It is part of: Blood Cancer Journal, 2020, vol. 10, num. 31
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ISSN: 2044-5385
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)

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