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http://hdl.handle.net/2445/178974
Title: | The Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition |
Author: | Gómez Valenzuela, Fernán Escobar, Enrico Pérez Tomás, Ricardo Montecinos, Viviana P. |
Keywords: | Càncer Inflamació Fenotip Cancer Inflammation Phenotype |
Issue Date: | 10-Jun-2021 |
Publisher: | Frontiers Media SA |
Abstract: | Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the super-cationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fonc.2021.686792 |
It is part of: | Frontiers in Oncology, 2021, vol. 11, num. 686792 |
URI: | http://hdl.handle.net/2445/178974 |
Related resource: | https://doi.org/10.3389/fonc.2021.686792 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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fonc-11-686792.pdf | 1.93 MB | Adobe PDF | View/Open |
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